Most Read Articles
Pearl Toh, 15 Jul 2019
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from the large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
15 Jul 2019
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.
2 days ago
Health-related quality of life (HRQoL) among patients with kidney stone is worse in those who are young and female than those who are older and male, according to a recent study. Non-Caucasian patients also have a lower HRQoL.
Tristan Manalac, 3 days ago
In patients with ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PPCI), admission Killip classification and creatinine and troponin levels are important cardiac mortality predictors, according to a recent Singapore study.

Herpes simplex virus infection uncommon in infants assessed for meningitis

20 Jan 2018

Infection with herpes simplex virus (HSV) occurs rarely in young infants undergoing meningitis evaluation, with the prevalence peaking in the second week of life and declining substantially in the second month of life, a study reports. 

Researchers examined 26,533 infants (median age 28 days; 44.2 percent female) who had undergone cerebrospinal fluid culture testing in one of 23 participating emergency departments. The proportion of encounters in which HSV infection (defined by a positive HSV polymerase chain reaction or viral culture) was identified was the primary outcome. Secondary outcomes included frequency of central nervous system (CNS) and disseminated HSV, and HSV testing and treatment patterns.

There were 112 HSV infections identified (0.42 percent; 95 percent CI, 0.35–0.51), and the median age of infected infants was 14 days (interquartile range, 9–24). Of the HSV cases, 90 (80.4 percent) occurred in weeks 1 to 4, 10 (8.9 percent) in weeks 5 to 6, and 12 (10.7 percent) in weeks 7 to 9. HSV infection was four times more likely to occur in 0–28-day-old infants than in 29–60-day-old infants (odds ratio, 3.9; 2.4–6.2).

Overall, 68 infants (0.26 percent) had CNS or disseminated HSV. The proportion of infants tested for HSV was 35 percent (range, 14–72) and to whom acyclovir was administered was 23 percent (range, 4–53), and this varied widely across sites.

“Our data emphasize the need for improved management strategies focused on the early identification of infants at both high and low risk of HSV infection,” researchers said.

More studies are needed to identify clinical and laboratory factors that can aid HSV infection risk stratification to enable the accurate identification of infants at high risk and in need of empirical HSV testing and treatment, while minimizing the testing and treatment of low-risk infants, they added.

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Most Read Articles
Pearl Toh, 15 Jul 2019
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from the large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
15 Jul 2019
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.
2 days ago
Health-related quality of life (HRQoL) among patients with kidney stone is worse in those who are young and female than those who are older and male, according to a recent study. Non-Caucasian patients also have a lower HRQoL.
Tristan Manalac, 3 days ago
In patients with ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PPCI), admission Killip classification and creatinine and troponin levels are important cardiac mortality predictors, according to a recent Singapore study.