Most Read Articles
06 Dec 2018
A strong belief in the necessity of medication is associated with better adherence to oral disease-modifying antirheumatic drugs (DMARDs) or prednisone, while higher self-efficacy correlates with poor adherence, in a diverse cohort of patients with rheumatoid arthritis (RA), suggests a study.
Pearl Toh, 22 hours ago
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
6 days ago
Low-dose administrations of haloperidol after thoracic surgery does not appear to prevent postoperative delirium, according to a new study.
4 days ago
Percutaneous coronary intervention (PCI) displays comparable rates of mortality and serious composite outcomes but a higher rate of target-vessel revascularization at 10 years relative to coronary artery bypass grafting (CABG) in patients with significant left main coronary artery (LMCA) disease, reports a study. On the other hand, CABG delivers lower mortality and serious composite outcome rates compared with PCI with drug-eluting stents after 5 years.

Herpes simplex virus contributes to infertility in men

13 Jan 2018

In male partners of infertile couples, infection with herpes simplex virus (HSV) appears to exert a negative effect on two equally important components of semen, spermatozoa and seminal fluid, which may in turn influence fertility, as shown in a recent study.

Researchers examined a total of 279 semen samples from males aged ≥18 years. All men had a semen analysis due to fertility evaluation following a failure to conceive with their partner after 1 year of unprotected intercourse.

Basic seminal parameters were analysed, with HSV infection detected by multiplex polymerase chain reaction (M-PCR) assay.

M-PCR assay detected HSV in 10.7 percent of samples, of which 7.5 percent had HSV-1 exclusively and 3.2 percent had HSV-2 exclusively.

There were significant associations observed between HSV-2 infection and hematospermia and a lower mean seminal volume, and between HSV-1 infection and a lower mean sperm count.

“Further studies enrolling a larger number of patients are necessary to confirm [the present] data and to elucidate the clinical relevance of HSV presence in semen,” researchers said.

HSV-1 causes oral and occasionally genital cold sores, whereas HSV-2 is the most common cause of genital herpes. The effect of HSV on infertility may be caused by epididymal and prostatic function, as indicated by reduced concentrations of neutral α­glucosidase and citrate in HSV-positive semen samples. Notably, it has been shown that antiviral treatment (acyclovir and valacyclovir) can help HSV-positive, infertile male patients achieve pregnancy. [Nat Rev Urol 2014;11:672-687]

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Most Read Articles
06 Dec 2018
A strong belief in the necessity of medication is associated with better adherence to oral disease-modifying antirheumatic drugs (DMARDs) or prednisone, while higher self-efficacy correlates with poor adherence, in a diverse cohort of patients with rheumatoid arthritis (RA), suggests a study.
Pearl Toh, 22 hours ago
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
6 days ago
Low-dose administrations of haloperidol after thoracic surgery does not appear to prevent postoperative delirium, according to a new study.
4 days ago
Percutaneous coronary intervention (PCI) displays comparable rates of mortality and serious composite outcomes but a higher rate of target-vessel revascularization at 10 years relative to coronary artery bypass grafting (CABG) in patients with significant left main coronary artery (LMCA) disease, reports a study. On the other hand, CABG delivers lower mortality and serious composite outcome rates compared with PCI with drug-eluting stents after 5 years.