Most Read Articles
Stephen Padilla, 2 days ago
The novel coronavirus disease (COVID-19) pandemic appears to have a significant impact on oncological care, according to a study, which stresses the need for psycho-oncological support for cancer patients.
01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
01 Aug 2020
Ensituximab, a chimeric monoclonal antibody targeting a variant of MUC5AC, shows modest clinical activity with good safety profile in patients with refractory colorectal cancer, according to data from a phase II study.
Roshini Claire Anthony, 30 Jul 2020

Frailty may indicate an increased risk of death from COVID-19, results of the COPE* study showed.

Hepatocyte microbeads safe for use in babies with acute liver failure

16 May 2020

Microencapsulated human hepatocytes in alginate may provide a safe and effective alternative to liver transplantation (LT) in infants with acute liver failure (ALF), a new study has shown.

The preliminary study enrolled eight children (median age, 28 days; 50 percent male) with ALF who were waiting for a suitable allograft for LT. Patients received intraperitoneal transplants of human hepatocyte microbeads (HMBs) and were followed for procedural complications, adverse immune responses and residual function of the HMBs.

In two participants, the cause of ALF could not be identified. Four children had neonatal haemochromatosis, one had disseminated herpes simplex virus type 1 and another had adenovirus-associated failure.

The median cell number transplanted was 2.4×107 cells/kg and the viability was assessed immediately after encapsulation. Viability, albumin and urea production decreased over time in culture. The implantation procedure was well-tolerated, and no patient showed post-infusion complications. Three participants continued receiving continuous renal replacement therapy as part of routine ALF management.

Half of the patients recovered spontaneously and ultimately had no need for LT. Three were bridged to LT, and one patient died. Long-term outcomes were good in all surviving patients.

HMBs were retrieved in the three patients who underwent LT. There were no signs of inflammation or adhesions between intra-abdominal organs, and light microscopy showed that the HMBs had maintained their physical integrity.

“Our data show that an optimized clinical grade HMBs can be feasibly and safely used for treatment in infants and children with ALF,” researchers said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Stephen Padilla, 2 days ago
The novel coronavirus disease (COVID-19) pandemic appears to have a significant impact on oncological care, according to a study, which stresses the need for psycho-oncological support for cancer patients.
01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
01 Aug 2020
Ensituximab, a chimeric monoclonal antibody targeting a variant of MUC5AC, shows modest clinical activity with good safety profile in patients with refractory colorectal cancer, according to data from a phase II study.
Roshini Claire Anthony, 30 Jul 2020

Frailty may indicate an increased risk of death from COVID-19, results of the COPE* study showed.