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04 Feb 2019
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Treatment with secukinumab results in a higher rate of remission or low-disease activity at week 16 in patients with psoriatic arthritis as compared with placebo, according to a posthoc analysis of the FUTURE 2 study. This effect is sustained at 2 years and is evident in both tumour necrosis factor inhibitor-experienced and -naïve patients.

Hepatocellular carcinoma incidence high in patients with alcoholic cirrhosis

29 Nov 2018

Hepatocellular carcinoma (HCC) is relatively common in patients with alcoholic cirrhosis, reports a new study.

Researchers evaluated 652 patients (median age 58.4 years; 68 percent male) with biopsy-confirmed compensated alcoholic cirrhosis, in whom the incidence of HCC was monitored. Other study outcomes included overall survival, event-free survival, liver-related mortality and hepatic focal lesions.

Majority of the participants (67.6 percent; n=441) were completely abstinent from alcohol, with a median duration of withdrawal of 24.7 months. At baseline, 44 patients (6.7 percent) had benign focal liver lesions, which were determined to be nonhepatocellular in 23, and hepatocellular in 11.

Over a median follow-up duration of 29 months, 125 patients developed liver lesions. The resulting 1- and 2-year cumulative incidence estimates were 13.3 percent and 20.8 percent, respectively. Most of these lesions remained benign, with only 43 patients (6.6 percent) eventually being diagnosed with HCC.

Researchers calculated the incidence rate of HCC to be 2.9 per 100 patient-years. The 1- and 2-year cumulative incidence rates were 1.8 percent and 5.2 percent, respectively.

Overall, majority of participants (77 percent; n=33) fulfilled the Milan criteria, but only 56 percent (n=24) ever received first-line curative treatment, such as liver transplantation, surgical resection and percutaneous ablation. Other patients opted for second-line liver treatments such as embolization and radiotherapy.

Seventy-three deaths were recorded, yielding a 2-year survival rate of 93 percent. Liver disease (44 percent; n=27) and liver decompensation (n=19) were the most prominent causes of death.

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Most Read Articles
04 Feb 2019
The carbon-chain length of saturated fatty acids appears to be an important factor in determining its role in cardiovascular health, a recent study has found.
6 days ago
Olanzapine confers a modest therapeutic effect on weight compared with placebo in adult outpatients with anorexia nervosa, a study has shown. However, it does not appear to offer significant benefit for psychological symptoms.
Pearl Toh, 3 days ago
A latest study at ISC 2019 shows that even patients with large-core stroke damage can have a good outcome after mechanical clot removal with endovascular thrombectomy (EVT), depending on the size of the infarct and time lapses between stroke onset and treatment.
Jairia Dela Cruz, 04 Feb 2019
Treatment with secukinumab results in a higher rate of remission or low-disease activity at week 16 in patients with psoriatic arthritis as compared with placebo, according to a posthoc analysis of the FUTURE 2 study. This effect is sustained at 2 years and is evident in both tumour necrosis factor inhibitor-experienced and -naïve patients.