Most Read Articles
Dr. Joseph Delano Fule Robles, 6 days ago

A team of investigators from the University of Hong Kong (HKU) identified high-risk Epstein Barr virus (EBV) variants present in 97 percent of nasopharyngeal carcinoma (NPC) cases.

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New drug applications approved by US FDA as of 01- 15 February 2019 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Tristan Manalac, 04 Dec 2018
In the era of Highly Active Antiretroviral Therapy (HAART), majority of the malignancies in AIDS patients are non-AIDS-defining cancers (NADC), according to an India study presented at the recently concluded European Society for Medical Oncology Asia 2018 Congress (ESMO Asia 2018).
Pearl Toh, 23 Aug 2018
Restoration of CD4/CD8 ratio on combination antiretroviral therapy (cART) was associated with decreased risk of Kaposi sarcoma (KS) while baseline CD8 count was related to non-Hogkin lymphoma (NHL) risk in people living with HIV (PLHIV) who had achieved viral suppression on cART, according to the COHERE* study presented at the AIDS International Conference (AIC) 2018.

Hepatitis E virus a common underlying cause of acute-on-chronic liver failure

02 Dec 2018

Alcohol contributes largely to the development of acute-on-chronic liver failure (ACLF), whereas hepatitis E virus (HEV) is the most common infectious cause of ACLF, suggesting a need for vaccination in such patients, a study has found.

Researchers examined 50 ACLF patients and 50 patients with stable chronic liver disease (CLD; controls), the majority of which were 31–60 years of age and male. They collected blood samples and performed two anti-HEV IgM enzyme-linked immunosorbent assays (ELISA; detection and capture). Additionally, they quantified HEV RNA in plasma and stool.

Results revealed ethanol to be the most common cause of acute insult in ACLF patients (54 percent), followed by HEV infection (14 percent).

IgM detection ELISA detected positivity for IgM antibodies to HEV in 10 ACLF patients vs two controls (20 percent vs 4 percent; p=0.0138). Only one ACLF patient showed HEV viremia (403 IU/ml), faecal shedding (2,790 IU/ml) and HEV antigenemia.

On the other hand, IgM capture ELISA detected five patients and one control. Agreement between detection and capture assays was 0.638 (kappa value).

The present data demonstrate a significant role of HEV in the causation of ACLF, highlighting a need to have an expanded diagnostic approach for HEV in such individuals, researchers said.

Researchers also pointed out that the time of presentation is of essence in the laboratory diagnosis of HEV. In the cohort, viremia, faecal shedding, antigenemia and IgM positivity were detected in one ACLF patient who presented on the fourth day of illness. In previous studies, 100 percent positivity for HEV RNA and antigen was observed in the first 3 days of illness, while the rate decreased by 46 percent for HEV RNA detection and by 12 percent for antigen detection by day 7 of illness. [J Med Virol 2013;85:823-827]

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Most Read Articles
Dr. Joseph Delano Fule Robles, 6 days ago

A team of investigators from the University of Hong Kong (HKU) identified high-risk Epstein Barr virus (EBV) variants present in 97 percent of nasopharyngeal carcinoma (NPC) cases.

4 days ago
New drug applications approved by US FDA as of 01- 15 February 2019 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Tristan Manalac, 04 Dec 2018
In the era of Highly Active Antiretroviral Therapy (HAART), majority of the malignancies in AIDS patients are non-AIDS-defining cancers (NADC), according to an India study presented at the recently concluded European Society for Medical Oncology Asia 2018 Congress (ESMO Asia 2018).
Pearl Toh, 23 Aug 2018
Restoration of CD4/CD8 ratio on combination antiretroviral therapy (cART) was associated with decreased risk of Kaposi sarcoma (KS) while baseline CD8 count was related to non-Hogkin lymphoma (NHL) risk in people living with HIV (PLHIV) who had achieved viral suppression on cART, according to the COHERE* study presented at the AIDS International Conference (AIC) 2018.