Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
2 days ago
Weight suppression appears to result in future onset of eating disorders characterized by dietary restriction or compensatory weight control behaviours, suggesting weight-suppressed women represent an at-risk group that may benefit from selective prevention programmes, a study has found.
3 days ago
Nocturia is a risk factor for mortality, according to the results of the Nagahama Study, which boasts of a low incidence of missing data and high representation of the general population.

Hepatitis C treatment benefit extends to nonhepatic cancers

13 Oct 2020

Treatment for hepatitis C virus (HCV) infection confers an added benefit of reducing the incidence of nonhepatic cancers, a study suggests.

The study drew data from the MarketScan Databases and included 62,078 patients with newly diagnosed HCV infection. Of the patients, 17,302 (28 percent) initiated HCV treatment, with 15,322 of them completing 8–16 weeks of therapy (minimally effective).

Multivariable, time‐varying Cox proportional hazards models showed that compared with untreated patients, those who initiated HCV treatment had an 11-percent lower risk of developing a nonhepatic cancer (hazard ratio [HR], 0.89, 95 percent confidence interval [Cl], 0.82–0.96).

The risk reduction was slightly higher when patients completed a minimally effective treatment (HR, 0.87, 95 percent Cl, 0.80–0.95). This was seen across subgroups defined by sex, age, and presence of cirrhosis or diabetes.

When analysis was stratified according to cancer or therapy subtypes, the association between HCV treatment and nonhepatic cancers was consistent for pancreatic and lung cancers and dual HCV therapy.

Overall, the findings suggest that treating HCV infection has the potential to reduce the burden of extrahepatic cancer associated with chronic HCV infection, according to the researchers.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Infectious Diseases - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
2 days ago
Weight suppression appears to result in future onset of eating disorders characterized by dietary restriction or compensatory weight control behaviours, suggesting weight-suppressed women represent an at-risk group that may benefit from selective prevention programmes, a study has found.
3 days ago
Nocturia is a risk factor for mortality, according to the results of the Nagahama Study, which boasts of a low incidence of missing data and high representation of the general population.