Most Read Articles
10 Jan 2021
Regular practice of yoga postures confers benefits for glucose control, oxidative stress, inflammatory response, and sleep quality in patients with type 2 diabetes, a study has found.
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.

Heavy drinkers at risk of salt-induced albuminuria

22 Nov 2020
Cues are not limited to the environment as they can include people, things and places; for example, spending a night out with a former drinking partner.

People who drink alcohol at a high frequency are more likely to develop albuminuria due to their salt intake, a recent study has found. Dietary salt restrictions of these people may have a renoprotective effect.

The study included 448 participants who were categorized into three according to self-reported drinking frequency: rarely, occasionally, and daily. Salt intake was estimated from single-spot urine specimens and the resulting urinary albumin-to-creatinine ratio (UACR) was calculated.

Most participants (n=235) reported occasional alcohol consumption, while 122 said that they drank daily; only 91 did so rarely. The three groups differed significantly in terms of age (p<0.001), with the daily drinkers being much older than the other two groups. Body mass index and current smoking were also greater among participants who drank daily.

Adjusted linear regression analysis found that the change in salt intake over a year of observation correlated significantly with changing log UACR (β, 0.16, 95 percent confidence interval [CI], 0.14–0.19; p<0.001). This meant that for every 1 g/day of change in salt intake, UACR increased by 1.17 times.

Because drinking frequency and changing salt intake also shared a significant adjusted interaction (p=0.088), the researchers sought to investigate the potential modifying effect alcohol consumption could exert on the link between salt intake and UACR.

They found that among higher-frequency drinkers, changes in UACR were much more sensitive to changing salt intake. For each 1g/day of change in salt intake, for instance, the β estimate for daily drinkers was 0.20 (95 percent CI, 0.13–0.27; p<0.001) while it was only 0.13 (95 percent CI, 0.06–0.19; p<0.001) in rare drinkers.

These suggest that the link between changing salt intake and UACR was around 1.5 times stronger in daily vs rare drinkers, the researchers pointed out.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
10 Jan 2021
Regular practice of yoga postures confers benefits for glucose control, oxidative stress, inflammatory response, and sleep quality in patients with type 2 diabetes, a study has found.
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.