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Yesterday
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Heart failure tied to poor renal outcome risk

07 Sep 2017
Scientists have created a gel that staves off heart failure after a heart attack

Heart failure (HF) is associated with higher risk of poor renal outcomes, such as incident chronic kidney disease (CKD) and rapid drop in estimated glomerular filtration rate (eGFR), in patients with normal kidney function, a new study reveals.

Baseline information and medication exposure and compliance of 156,743 US veterans were collected. All participants had eGFR 60 mL min-1 1.73 m-2 and congestive HF. Study outcomes were incident CKD, rate of kidney function decline and a composite of incident CKD and mortality.

Over a median follow-up of 7.6 years, a total of 361,488 CKD events in the cohort were recorded, yielding an event rate of 16.04 per 1,000 patient-years. The CKD event rate was higher in veteran HF patients (68.90 per 1,000 person-years) than in those without (14.48 per 1,000 person-years).

Multivariate analysis showed a positive association between incident CKD and HF (hazard ratio [HR], 2.12; 95 percent CI, 2.10 to 2.14).

For the composite outcome, 986,588 events were reported. The incidence rates were again higher in HF patients (164.66 per 1,000 person-years) than in non-HF veterans (40.20 per 1,000 person-years). A positive association between HF and the composite outcome was also calculated (HR, 2.06; 2.05 to 2.08).

The overall prevalence of rapid eGFR decline was 9.12 percent and was higher in patients with HF (21.69 percent) than in those without (8.56 percent). Rapid eGFR decline was also positively associated with incident CKD (HR, 2.13; 2.10 to 2.17).

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Most Read Articles
Yesterday
Long-term use of benzodiazepines is independently associated with lower diastolic and systolic blood pressure in ambulatory blood pressure monitoring (ABPM) among older but not younger patients, a study has found.
3 days ago
There appears to be a paradox in the context of smoking and the risk of psoriatic arthritis (PsA), such that current smoking increases the risk of developing PsA in the general population but protects against the same risk among patients with psoriasis, according to a study.
4 days ago
Moderate increases in physical activity levels may translate to significant reductions in both fasting glucose and HbA1c, a study has found.
Pearl Toh, 14 Nov 2017
Performing percutaneous coronary intervention (PCI) on culprit lesion only, rather than a multivessel PCI, reduces the 30-day composite risk of death or severe renal failure in patients with acute myocardial infarction (MI) complicated by cardiogenic shock and multivessel disease, according to the CULPRIT-SHOCK* study presented at the TCT 2017 Congress held in Denver, Colorado, US.