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Heart failure hospitalization still a problem among diabetics

10 Jan 2021

Among diabetic individuals, the incidence of hospitalization for heart failure (HHF) is low but not negligible, a new study finds. In addition, the use of sodium-glucose cotransporter 2 inhibitors (SGLT2is) could help suppress HHF.

Drawing from a contemporary administrative claims database in Japan, the researchers enrolled 23,340 patients who had started using oral glucose-lowering drugs for the treatment of type 2 diabetes mellitus. Participants were followed for a mean of 2.8 years, during which the incidence of HHF was monitored; the secondary outcome was hospitalization for either myocardial infarction (MI) or stroke.

During the observation period, a total of 681 HHFs were reported, resulting in an incidence rate of 10.4 per 1,000 person-years. Hospitalization for MI was lower at 267 cases (4.1 per 1,000 person-years), while that for stroke was only slightly higher (n=847 cases; 12.9 per 1,000 person-years).

The respective 5-year cumulative incidence rates were 5.4 percent, 1.9 percent, and 6.1 percent. When analysis was restricted to patients who had no diagnosis of cardiovascular disease at baseline, the resulting cumulative incidences were 4.6 percent, 1.6 percent, and 4.5 percent, respectively.

In a subset of patients (n=2,849), the researchers sought to quantify the potential effect of initiating SGLT2i treatment using published relative risk reduction estimates from two prior trials; all patients satisfied the eligibility criteria of these two trials.

In this subset, the cumulative case count of HHF without any external medication was estimated to be 97.1 over 5 years. If 75 percent of these patients were to be treated with SGLT2is, the resulting event count was predicted to drop to 75.6 over the same time span.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Yesterday
Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.