Most Read Articles
Pearl Toh, 6 days ago
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
5 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 4 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.

Pearl Toh, 25 Jun 2020
The type of face mask matters, in addition to sterilization method, in influencing subsequent filtration efficiency after sterilization process for reuse, a new study finds.

Heart failure, CV mortality risk higher with aromatase inhibitors vs tamoxifen

25 Feb 2020

Aromatase inhibitors seem to confer heightened risks of heart failure and cardiovascular (CV) mortality when compared with tamoxifen, a study has found.

The study involved 23,525 newly diagnosed breast cancer patients, among whom 17,922 initiated hormonal therapy with either an aromatase inhibitor (n=8,139) or tamoxifen (n=9,783). Anastrozole was the most commonly used aromatase inhibitor (57.7 percent), followed by letrozole (41.7 percent) and exemestane (0.6 percent).

In Cox proportional hazards models with inverse probability of treatment, aromatase inhibitor vs tamoxifen users had an 86-percent increased risk of heart failure (incidence rate, 5.4 vs 1.8 per 1,000 person-years; hazard ratio [HR], 1.86, 95 percent confidence interval [CI], 1.14–3.03) and 50-percent higher risk of CV mortality (incidence rate, 9.5 vs 4.7 per 1,000 person-years; HR, 1.50, 95 percent CI, 1.11–2.04).

Aromatase inhibitors were also associated with a trend toward heightened risks of myocardial infarction (incidence rate, 3.9 vs 1.8 per 1,000 person-years; HR, 1.37, 95 percent CI, 0.88–2.13) and ischaemic stroke (incidence rate, 5.6 vs 3.2 per 1,000 person-years; HR, 1.19, 95 percent CI, 0.82–1.72). The estimates were robust to several sensitivity analyses.

The higher risk of CV events associated with aromatase inhibitors should be balanced with their favourable clinical benefits relative to tamoxifen, the researchers said.

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Most Read Articles
Pearl Toh, 6 days ago
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
5 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 4 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.

Pearl Toh, 25 Jun 2020
The type of face mask matters, in addition to sterilization method, in influencing subsequent filtration efficiency after sterilization process for reuse, a new study finds.