HDL particles inversely associated with myocardial infarction
Lipids and lipoproteins are similarly linked to myocardial infarction (MI) and ischaemic stroke (IS), but not to intracerebral haemorrhage (ICH), according to a study.
“Within high-density lipoprotein (HDL) particles, cholesterol concentrations were inversely associated, whereas triglyceride concentrations were positively associated with MI,” researchers said. “Glycoprotein acetyls and several nonlipid-related metabolites [correlated] with all three diseases.”
A positive association existed between lipoprotein particles (very low-, intermediate- and low-density) with MI and IS. HDL particles, on the other hand, were inversely associated with MI apart from small HDL. No lipoprotein particles correlated with ICH.
Cholesterol in large HDL had an inverse relationship with MI and IS (odds ratio [OR], 0.79 and 0.88, respectively), but cholesterol in small HDL showed no association (OR, 0.99 and 1.06, respectively). Triglycerides within all lipoproteins, as well as most HDL particles, positively correlated with MI, with a similar pattern for IS.
Glycoprotein acetyls, ketone bodies, glucose and docosahexaenoic acid showed an association with all three diseases. In addition. The 225 metabolic markers had consistent associations between MI and IS, but not with ICH.
A nested case-control study was conducted to examine the associations of plasma metabolic markers with risks of incident MI, IS and ICH. A total of 912 MI, 1,146 IS and 1,138 ICH patients and 1,466 common control participants (aged 30‒79 years) from the China Kadoorie Biobank were included.
Using nuclear magnetic resonance spectroscopy, researchers measured 225 metabolic markers in baseline plasma samples. They also used logistic regression to estimate adjusted ORs for a 1-SD higher metabolic marker.
“Blood lipids are established risk factors for MI, but uncertainty persists about the relevance of lipids, lipoprotein particles and circulating metabolites for MI and stroke subtypes,” researchers noted.