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HDL particles inversely associated with myocardial infarction

12 Feb 2018

Lipids and lipoproteins are similarly linked to myocardial infarction (MI) and ischaemic stroke (IS), but not to intracerebral haemorrhage (ICH), according to a study.

“Within high-density lipoprotein (HDL) particles, cholesterol concentrations were inversely associated, whereas triglyceride concentrations were positively associated with MI,” researchers said. “Glycoprotein acetyls and several nonlipid-related metabolites [correlated] with all three diseases.”

A positive association existed between lipoprotein particles (very low-, intermediate- and low-density) with MI and IS. HDL particles, on the other hand, were inversely associated with MI apart from small HDL. No lipoprotein particles correlated with ICH.

Cholesterol in large HDL had an inverse relationship with MI and IS (odds ratio [OR], 0.79 and 0.88, respectively), but cholesterol in small HDL showed no association (OR, 0.99 and 1.06, respectively). Triglycerides within all lipoproteins, as well as most HDL particles, positively correlated with MI, with a similar pattern for IS.

Glycoprotein acetyls, ketone bodies, glucose and docosahexaenoic acid showed an association with all three diseases. In addition. The 225 metabolic markers had consistent associations between MI and IS, but not with ICH.

A nested case-control study was conducted to examine the associations of plasma metabolic markers with risks of incident MI, IS and ICH. A total of 912 MI, 1,146 IS and 1,138 ICH patients and 1,466 common control participants (aged 30‒79 years) from the China Kadoorie Biobank were included.

Using nuclear magnetic resonance spectroscopy, researchers measured 225 metabolic markers in baseline plasma samples. They also used logistic regression to estimate adjusted ORs for a 1-SD higher metabolic marker.

“Blood lipids are established risk factors for MI, but uncertainty persists about the relevance of lipids, lipoprotein particles and circulating metabolites for MI and stroke subtypes,” researchers noted.

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Most Read Articles
01 Mar 2016
Combination therapy with ezetimibe/statin improved low-density lipoprotein (LDL) cholesterol levels and cardiovascular outcomes in patients with acute coronary syndrome (ACS), as stated in a 16-week one-centre, prospective, randomised, open-label clinical trial.
13 Aug 2016
Prasugrel is superior than clopidogrel in the treatment of acute coronary syndrome (ACS) and ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) as presented in a study.
01 Mar 2016
Earlier oral β blocker administration is substantially correlated with lower rates of left ventricular (LV) dysfunction and in-hospital mortality in acute coronary syndrome patients, according to a study.
16 Dec 2018
The absence of the classical symptom of chest pain in patients with acute myocardial infarction (AMI) appears to be associated with more complications and higher short- and long-term mortality rates, particularly in younger and healthier patients, according to a study.