Most Read Articles
18 Apr 2018
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HCV infection ups risk of gallstones in patients with chronic liver disease

31 Mar 2018
Those with a history of gallstone disease have a 23% increased risk for coronary heart disease.

In patients with chronic liver disease (CLD), concurrent hepatitis C virus (HCV) infection appears to increase the risk of developing gallstones, a recent China study has shown.

Outcomes in 267 CLD patients with gallstones (median age 61 years; 42.7 percent male) were compared with outcomes in 1,015 CLD patients without gallstones (controls; median age 56 years; 43.6 percent male). Logistic regression analysis was used to calculate for the odds ratios [ORs] of the comparisons.

Multivariable adjusted analysis showed that participants with liver cirrhosis had a significantly higher risk of gallstones than those without cirrhosis (adjusted OR, 2.343; 95 percent CI, 1.710–3.211; p<0.001). The likelihood of developing gallstones was similarly higher in those with HCV-related vs hepatitis B-related CLD (adjusted OR, 1.582; 1.066–2.347; p=0.023).

Age also appeared to be a significant factor, with those 60 years of age being at elevated risks of gallstones relative to their younger counterparts (adjusted OR, 1.848; 1.378–2.477; p<0.001).

Researchers then restricted analysis to the CLD patients with liver cirrhosis. In this subpopulation, HCV-related CLD (adjusted OR, 1.601; 1.063–2.413; p=0.024) and age 60 years (adjusted OR, 1.712; 1.181–2.481; p=0.005) remained as significant risk factors for gallstone development. On the other hand, cirrhosis severity was unrelated to gallstone development, regardless of age.

“[T]he risk of gallstone development in Chinese CLD patients was significantly associated with the occurrence of liver cirrhosis, older age and HCV infection. Furthermore, patients infected with HCV formed more gallstones than did patients infected with HBV,” said researchers.

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Most Read Articles
18 Apr 2018
Higher intake levels of coffee appear to be associated with reduced risk of developing chronic kidney disease, according to data from the Atherosclerosis Risk in Communities Study.
Jairia Dela Cruz, 5 days ago
Infants delivered via caesarean section may be at increased risk of developing acute lymphoblastic leukaemia, according to a US study. Altered microbiota colonization is a possible explanation for this risk, although clear biological mechanisms have yet to be established.
4 days ago
Treatment with danegaptide does not improve myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention, according to the results of a phase II study.
4 days ago
Men with high levels of exposure to diesel exhaust are at greater risk of developing amyotrophic lateral sclerosis (AML), as shown in a recent study. This is not true for women.