Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
6 days ago
Testosterone treatment may slightly improve sexual functioning and quality of life in men without underlying organic causes of hypogonadism, but it offers little to no benefit for other common symptoms of ageing, according to a study. In addition, long-term efficacy and safety of this therapy remain unknown.
Stephen Padilla, 4 days ago
The Lancet Commission on Hypertension Group has recently released a position statement that contains a list of recommendations for the improvement of accuracy standards for devices that measure blood pressure (BP).

HCC risk tied to hepatitis B-core related antigen level

09 Dec 2019
Hepatitis B is still widely prevalent worldwide despite effective vaccination programmes in many countries.

Concentrations of hepatitis B core-related antigen (HBcrAg) may help predict the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infections, a new study has shown.

Researchers retrieved clinical data of 2,666 adult HBV patients (aged >28 years; 60.62 percent male) who had long-term follow-up information available. None of the participants received antiviral treatment during follow-up. The primary study endpoint was the link between serum HBcrAg levels and HCC incidence.

Almost half of the participants (47.6 percent; n=1,271) had serum HBcrAg levels <10 KU/mL. Moderate and high viral loads were detected in 20.59 percent (n=549) and 39.01 percent (n=1,040) of the patients, respectively. HBcrAg concentration and viral load, expressed as HBV DNA level, were significantly correlated (p<0.001).

Over a mean follow-up of 15.95±4.78 years, 209 new cases of HCC were reported, resulting in an overall incidence rate of 4.91 per 1,000 person-years. The average time to malignancy was 12.22±5.29 years.

HBcrAg emerged as a significant independent risk factor for HCC development. Those with serum levels 10–99 (hazard ratio [HR], 3.57, 95 percent confidence interval [CI], 2.27–5.62) ,100–999 (HR, 5.96, 95 percent CI, 3.73–9.52) and 1,000 (HR, 6.38, 95 percent CI, 4.24–9.59) KU/mL were significantly more likely to develop HCC than their counterparts with <10 KU/mL HBcrAg.

These associations remained statistically significant even after adjusting for confounders, such as age, sex and HBV genotype.

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Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
6 days ago
Testosterone treatment may slightly improve sexual functioning and quality of life in men without underlying organic causes of hypogonadism, but it offers little to no benefit for other common symptoms of ageing, according to a study. In addition, long-term efficacy and safety of this therapy remain unknown.
Stephen Padilla, 4 days ago
The Lancet Commission on Hypertension Group has recently released a position statement that contains a list of recommendations for the improvement of accuracy standards for devices that measure blood pressure (BP).