Most Read Articles
Jairia Dela Cruz, 22 Apr 2020
A wristwatch-like device that monitors pulse, breathing and blood oxygen levels of the user allows physicians to provide care remotely both in hospital and nontraditional settings, and may help in the fight against the coronavirus disease 2019 (COVID-19) pandemic.
Roshini Claire Anthony, 6 days ago

The use of a vaginal cleansing intervention prior to Caesarean delivery reduced the incidence of surgical site infections (SSIs), according to a study presented at ACOG 2020. However, the addition of intravenous (IV) azithromycin prophylaxis had no added impact on SSI rates. 

Pank Jit Sin, 21 May 2020

Persons suffering from asthma should pay particular attention to SARS-CoV-2 precautionary measures such as social distancing, regular handwashing, and wearing of masks on top of keeping their asthma in control. This is because data collected so far paints a bleaker picture for asthmatics than the normal population should they catch COVID-19.

Stephen Padilla, 5 days ago
Herd immunity will not work in the novel coronavirus disease (COVID-19), according to an infectious disease expert who addressed over 3,600 primary care physicians (PCP) from Asia Pacific at the inaugural webcast of the MIMS COVID Conversations Series.

HCC a common liver-related event in successfully treated HCV infection

09 Mar 2020

Hepatocellular carcinoma (HCC) is the most common liver-related event (LRE) in hepatitis C virus (HCV) patients with compensated, advanced chronic liver disease (cACLD) who have achieved sustained virological response through direct-acting antivirals (DAA), reports a new study.

The study included 572 eligible cACLD patients (mean age, 63.7 years; 49.3 percent male). LREs were defined as hepatorenal syndromes, variceal bleeding, ascites, hepatic encephalopathy or HCC. Surveillance began after DAA therapy was finished, though only LREs occurring after SVR was confirmed were included in the analysis.

At baseline, mean liver stiffness was 20.2±10.4 kPa, which dropped to 13.9±9.2 kPa after 1 year, representing a significant 28.9-percent improvement (p<0.001).

Over a median follow-up of 2.9 years, five participants died from nonliver causes (0.9 percent) and 32 patients developed LREs (5.6 percent). HCC occurred in 25 of these patients (4.4 percent) and emerged as the most common LRE, with an incidence rate of 1.5 per 100 patient-years. There were no liver-related deaths.

Other LREs included portal hypertension related to decompensation (n=5, 0.9 percent) and cholangiocarcinoma (n=2, 0.3 percent).

Multivariable Cox regression analysis found that follow-up levels of albumin (hazard ratio [HR], 0.08, 95 percent confidence interval [CI], 0.02–0.25; p<0.001) and having liver stiffness <10 kPa (HR, 0.33, 95 percent CI, 0.11–0.96; p=0.042) were both significantly protective against HCC development.

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Most Read Articles
Jairia Dela Cruz, 22 Apr 2020
A wristwatch-like device that monitors pulse, breathing and blood oxygen levels of the user allows physicians to provide care remotely both in hospital and nontraditional settings, and may help in the fight against the coronavirus disease 2019 (COVID-19) pandemic.
Roshini Claire Anthony, 6 days ago

The use of a vaginal cleansing intervention prior to Caesarean delivery reduced the incidence of surgical site infections (SSIs), according to a study presented at ACOG 2020. However, the addition of intravenous (IV) azithromycin prophylaxis had no added impact on SSI rates. 

Pank Jit Sin, 21 May 2020

Persons suffering from asthma should pay particular attention to SARS-CoV-2 precautionary measures such as social distancing, regular handwashing, and wearing of masks on top of keeping their asthma in control. This is because data collected so far paints a bleaker picture for asthmatics than the normal population should they catch COVID-19.

Stephen Padilla, 5 days ago
Herd immunity will not work in the novel coronavirus disease (COVID-19), according to an infectious disease expert who addressed over 3,600 primary care physicians (PCP) from Asia Pacific at the inaugural webcast of the MIMS COVID Conversations Series.