Most Read Articles
Roshini Claire Anthony, 01 Dec 2020

An evidence-based, multifaceted intervention aimed at reducing haemodialysis catheter-related bloodstream infections (HD-CRBSIs) failed to improve this outcome, results of the REDUCCTION* trial showed.

Pearl Toh, 3 days ago
While it is well known that COVID-19 illness is associated with coagulopathy, the optimal anticoagulation strategy remains elusive, and two studies presented at the ASH 2020 Congress further add to the growing debate on the appropriate anticoagulant dose for hospitalized patients with COVID-19.
Tristan Manalac, 20 hours ago
People are more likely to follow social distancing measures for the novel coronavirus disease (COVID-19) pandemic when they thought that their friends and family did the same, too, according to a new study.

HCC a common liver-related event in successfully treated HCV infection

09 Mar 2020

Hepatocellular carcinoma (HCC) is the most common liver-related event (LRE) in hepatitis C virus (HCV) patients with compensated, advanced chronic liver disease (cACLD) who have achieved sustained virological response through direct-acting antivirals (DAA), reports a new study.

The study included 572 eligible cACLD patients (mean age, 63.7 years; 49.3 percent male). LREs were defined as hepatorenal syndromes, variceal bleeding, ascites, hepatic encephalopathy or HCC. Surveillance began after DAA therapy was finished, though only LREs occurring after SVR was confirmed were included in the analysis.

At baseline, mean liver stiffness was 20.2±10.4 kPa, which dropped to 13.9±9.2 kPa after 1 year, representing a significant 28.9-percent improvement (p<0.001).

Over a median follow-up of 2.9 years, five participants died from nonliver causes (0.9 percent) and 32 patients developed LREs (5.6 percent). HCC occurred in 25 of these patients (4.4 percent) and emerged as the most common LRE, with an incidence rate of 1.5 per 100 patient-years. There were no liver-related deaths.

Other LREs included portal hypertension related to decompensation (n=5, 0.9 percent) and cholangiocarcinoma (n=2, 0.3 percent).

Multivariable Cox regression analysis found that follow-up levels of albumin (hazard ratio [HR], 0.08, 95 percent confidence interval [CI], 0.02–0.25; p<0.001) and having liver stiffness <10 kPa (HR, 0.33, 95 percent CI, 0.11–0.96; p=0.042) were both significantly protective against HCC development.

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Most Read Articles
Roshini Claire Anthony, 01 Dec 2020

An evidence-based, multifaceted intervention aimed at reducing haemodialysis catheter-related bloodstream infections (HD-CRBSIs) failed to improve this outcome, results of the REDUCCTION* trial showed.

Pearl Toh, 3 days ago
While it is well known that COVID-19 illness is associated with coagulopathy, the optimal anticoagulation strategy remains elusive, and two studies presented at the ASH 2020 Congress further add to the growing debate on the appropriate anticoagulant dose for hospitalized patients with COVID-19.
Tristan Manalac, 20 hours ago
People are more likely to follow social distancing measures for the novel coronavirus disease (COVID-19) pandemic when they thought that their friends and family did the same, too, according to a new study.