Most Read Articles
12 Jun 2019
Urogenital infections remain a major reason for women to visit their family physician and their subsequent referral to obstetrics and gynaecology or urology specialists. The association between abnormal vaginal microbiota and an increased risk of contracting sexually transmitted diseases (STDs), as well as an increased rate of preterm labour, indicates the need to better understand and manage urogenital health in women. Probiotics are “live microorganisms which, when administered in adequate amounts, confer a health benefit on the host”. As such, there is a sound rationale for using probiotics to maintain female vaginal and bladder health.
01 Jan 2019
Twice-daily administration of a combined Lactobacillus rhamnosus and Lactobacillus helveticus probiotic in children with suspected gastroenteritis fails to prevent the development of moderate-to-severe gastroenteritis within 2 weeks after presentation, as shown in a recent study.
25 Oct 2018
Human papillomaviruses (HPVs) are commonly found in the oral cavity, but it does not appear that oral HPVs contribute to an increased risk of oesophageal cancer, according to a study.
Natalia Reoutova, 07 Jul 2020

A retrospective cohort study of nearly 2,000 patients hospitalized with coronavirus disease 2019 (COVID-19) found a higher rate of ischaemic stroke compared with a cohort of patients with influenza A/B.

HBV infection a favourable prognostic marker in operable oesophageal cancer

05 Jul 2019

Survival in oesophageal cancer patients undergoing oesophagectomy appears to be better in the presence of hepatitis B virus (HBV) infection, a study has found.

The study included 2,004 consecutive patients who underwent surgery for their oesophageal cancer. Serum HBV markers were tested using ELISA, and results showed that 253 patients (12.6 percent) were positive for HBV infection (HBsAg-positive).

Compared with those who were not infected, patients who were HBsAg-positive were more likely to have early pathological T stage (39.5 percent vs 26.3 percent; p=0.002) and never consumed alcohol (74.3 percent vs 68.5 percent; p=0.033). The HBsAg-positive group also had a lower frequency of liver metastasis (0.8 percent vs 3.1 percent; p=0.036) and extrahepatic metastasis (3.2 percent vs 6.7 percent; p=0.028).

HBsAg positivity was associated with about a 20-percent increase in disease-free survival (DFS; hazard ratio [HR], 0.79, 95 percent CI, 0.66–0.94; p=0.007) and overall survival (OS; HR, 0.80, 0.65–0.95; p=0.020) when compared with HBsAg negativity.

Subgroup analysis showed that the survival gains associated with HBV infection were greater among patients with oesophageal squamous cell carcinoma (ESCC) and advanced pathologic stage (III–IV).

The present data suggest that HBV infection might serve as a useful biomarker to predict survival in patients with oesophageal cancer, especially advanced pathological stage ESCC patients, researchers said, adding that the infection activates the liver-associated immunity to decrease the incidence of liver metastasis in cancer patients.

Additional prospective studies are warranted to determine the prognostic and treatment value of HBV infection in oesophageal cancer, the researchers added.

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Most Read Articles
12 Jun 2019
Urogenital infections remain a major reason for women to visit their family physician and their subsequent referral to obstetrics and gynaecology or urology specialists. The association between abnormal vaginal microbiota and an increased risk of contracting sexually transmitted diseases (STDs), as well as an increased rate of preterm labour, indicates the need to better understand and manage urogenital health in women. Probiotics are “live microorganisms which, when administered in adequate amounts, confer a health benefit on the host”. As such, there is a sound rationale for using probiotics to maintain female vaginal and bladder health.
01 Jan 2019
Twice-daily administration of a combined Lactobacillus rhamnosus and Lactobacillus helveticus probiotic in children with suspected gastroenteritis fails to prevent the development of moderate-to-severe gastroenteritis within 2 weeks after presentation, as shown in a recent study.
25 Oct 2018
Human papillomaviruses (HPVs) are commonly found in the oral cavity, but it does not appear that oral HPVs contribute to an increased risk of oesophageal cancer, according to a study.
Natalia Reoutova, 07 Jul 2020

A retrospective cohort study of nearly 2,000 patients hospitalized with coronavirus disease 2019 (COVID-19) found a higher rate of ischaemic stroke compared with a cohort of patients with influenza A/B.