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Jairia Dela Cruz, 30 Aug 2019
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Dr. Joseph Delano Fule Robles, 23 Jan 2019

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Pank Jit Sin, 27 Jun 2019

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HBV infection a favourable prognostic marker in operable oesophageal cancer

05 Jul 2019

Survival in oesophageal cancer patients undergoing oesophagectomy appears to be better in the presence of hepatitis B virus (HBV) infection, a study has found.

The study included 2,004 consecutive patients who underwent surgery for their oesophageal cancer. Serum HBV markers were tested using ELISA, and results showed that 253 patients (12.6 percent) were positive for HBV infection (HBsAg-positive).

Compared with those who were not infected, patients who were HBsAg-positive were more likely to have early pathological T stage (39.5 percent vs 26.3 percent; p=0.002) and never consumed alcohol (74.3 percent vs 68.5 percent; p=0.033). The HBsAg-positive group also had a lower frequency of liver metastasis (0.8 percent vs 3.1 percent; p=0.036) and extrahepatic metastasis (3.2 percent vs 6.7 percent; p=0.028).

HBsAg positivity was associated with about a 20-percent increase in disease-free survival (DFS; hazard ratio [HR], 0.79, 95 percent CI, 0.66–0.94; p=0.007) and overall survival (OS; HR, 0.80, 0.65–0.95; p=0.020) when compared with HBsAg negativity.

Subgroup analysis showed that the survival gains associated with HBV infection were greater among patients with oesophageal squamous cell carcinoma (ESCC) and advanced pathologic stage (III–IV).

The present data suggest that HBV infection might serve as a useful biomarker to predict survival in patients with oesophageal cancer, especially advanced pathological stage ESCC patients, researchers said, adding that the infection activates the liver-associated immunity to decrease the incidence of liver metastasis in cancer patients.

Additional prospective studies are warranted to determine the prognostic and treatment value of HBV infection in oesophageal cancer, the researchers added.

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Most Read Articles
Jairia Dela Cruz, 30 Aug 2019
Infection with hepatitis B virus (HBV) does not appear to independently affect pregnancy outcomes, although it contributes to prolonged infertility, higher odds of secondary infertility, ovulatory disorders and reduced implantation rate, a study has found.
Dr. Joseph Delano Fule Robles, 23 Jan 2019

Scientists from the Department of Microbiology, University of Hong Kong (HKU) recently discovered a compound with broad antiviral activity against viruses causing Middle East Respiratory Syndrome (MERS), avian flu (H7N9), severe acute respiratory syndrome (SARS) and Zika fever.

Pank Jit Sin, 27 Jun 2019

How does it feel to be told one has contracted HIV? How equipped are doctors when breaking the news to a patient that he or she has been diagnosed with HIV? Are we able to provide people living with HIV (PLHIV) the counselling and skills required to take them through this difficult period of life? MIMS Doctor speaks to Dr Julian Hong, a general physician practicing in Singapore, about the challenges faced by both patients and doctors when faced with the difficult topic of HIV.