Most Read Articles
Roshini Claire Anthony, 5 days ago

Children who are fully vaccinated against the flu, ie, receive the recommended number of influenza vaccine doses, have a lower risk of acquiring influenza compared with those who are partially vaccinated, a US study found.

06 Jul 2020
Routinely used for treating cardiovascular diseases, statins have been shown to benefit other conditions, and new evidence suggests that using the drug at high intensity reduces the risk of hip or knee replacement, an effect that may be specific to rheumatoid arthritis.
Yesterday
Treatment with levothyroxine appears to have no significant impact on systolic and diastolic heart function in older adults with mild subclinical hypothyroidism as compared with placebo, results of a study have shown.
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.

HbA1c tied to coronary artery disease risk

27 May 2020

Glycated haemoglobin (HbA1c) levels appear to be an independent predictor of coronary artery disease (CAD) in patients with ST-elevation myocardial infarction (STEMI), a new study has found.

The researchers conducted a cross-sectional analysis of 8,370 STEMI patients with available HbA1c measurements. The study outcome was CAD, as defined by coronary angiogram performed upon admission. Lesions with 50-percent-diameter stenosis in the left main coronary artery or in three major coronary arteries was defined as a multivessel disease (MVD).

Of the participants, 4,972 (mean age, 62.32±11.92 years; 82.33 percent male) did not have diabetes mellitus, while the remaining 3,398 (mean age, 60.91±13.13 years; 74.87 percent male) did.

Multivariable analysis found that diabetics were at a significantly higher risk of tachycardia (odds ratio [OR], 1.40, 95 percent confidence interval [CI], 1.21–1.61), of a higher Killip class (OR, 1.12, 95 percent CI, 1.01–1.25) and of MVD (OR, 1.42, 95 percent CI, 1.27–1.58).

HbA1c showed a similar effect, significantly correlating with a greater likelihood of tachycardia (OR, 1.11, 95 percent CI, 1.07–1.15) and MVD (OR, 1.11, 95 percent CI, 1.07–1.15). Risk estimates were calculated for every 1-percent increment in HbA1c.

Using the standard HbA1c cutoffs in clinical practice, researchers continued to find correlations between diabetes and CAD outcomes. HbA1c levels 6.5 percent, for example, significantly increased the risk of MVD, as did concentrations exceeding 7 percent.

“[F]or post-MI patients with DM and other comorbidities, physicians may use the number of stenosed vessels to improve cardiovascular risk assessment, and consider more intensive and individually tailored glycaemic control,” said researchers

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 5 days ago

Children who are fully vaccinated against the flu, ie, receive the recommended number of influenza vaccine doses, have a lower risk of acquiring influenza compared with those who are partially vaccinated, a US study found.

06 Jul 2020
Routinely used for treating cardiovascular diseases, statins have been shown to benefit other conditions, and new evidence suggests that using the drug at high intensity reduces the risk of hip or knee replacement, an effect that may be specific to rheumatoid arthritis.
Yesterday
Treatment with levothyroxine appears to have no significant impact on systolic and diastolic heart function in older adults with mild subclinical hypothyroidism as compared with placebo, results of a study have shown.
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.