Most Read Articles
04 Oct 2018
A week of preoperative oral antibiotics prior to percutaneous nephrolithotomy does not appear to confer any benefit in patients at low risk for infectious complications, suggests a recent study. Perioperative antibiotics according to the American Urological Association (AUA) Best Practice Statement is deemed sufficient.
09 Oct 2018
The use of statins does not appear to influence the immature platelet count in patients with coronary artery disease (CAD), a new study has shown.
Rachel Soon, 01 Sep 2018

MIMS Pharmacist presents an overview of a standardized extract of Pinus pinaster bark, and its potential role in slowing down the progression of diabetic retinopathy.

Dr. Lau Hui Ling, 01 Aug 2017
Oral contraceptive selection should be individualized for each patient to yield maximum benefit.

Halobetasol propionate with tazarotene effective, safe for psoriasis

22 Jul 2018
Psoriasis affecting the upper limb

Halobetasol propionate plus tazarotene (HP/TAZ) significantly reduces the clinical severity of psoriasis with minimal adverse side effects, a recent study has shown.

The present analysis included data from two randomized, double-blind, multicentre, controlled phase 3 studies, where 418 psoriasis patients (65.1 percent male) were randomly assigned 2:1 to receive HP/TAZ lotion or vehicle control once daily for 8 weeks. The study outcomes included treatment success and safety.

At week 8, 35.8 percent (study 1) and 45.3 percent (study 2) of the participants who received HP/TAZ achieved the primary efficacy outcome of at least a 2-grade improvement in Investigator’s Global Assessment score from baseline. This was significantly higher than in the vehicle control groups (7.0 and 12.5 percent, respectively; p<0.001 for both).

Similarly, at the same time point in study 1 and study 2, significantly more participants in the HP/TAZ vs vehicle control group showed improvements in erythema (44.2 percent and 49.6 percent vs 10.0 percent and 18.7 percent) and plaque elevation (59.3 percent and 59.7 percent vs 17.9 percent and 21.3 percent; p<0.001 for all).

In terms of safety, adverse events were more common in participants who received the HP/TAZ lotion than in those who received the control (35.9 percent vs 21.4 percent). Majority of the adverse events (AEs) were mild or moderate in severity (85.6 percent); only three serious AEs were reported, none of which were related to the HP/TAZ lotion,

The most common treatment-related AEs were contact dermatitis, pruritus and pain the application site.

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Most Read Articles
04 Oct 2018
A week of preoperative oral antibiotics prior to percutaneous nephrolithotomy does not appear to confer any benefit in patients at low risk for infectious complications, suggests a recent study. Perioperative antibiotics according to the American Urological Association (AUA) Best Practice Statement is deemed sufficient.
09 Oct 2018
The use of statins does not appear to influence the immature platelet count in patients with coronary artery disease (CAD), a new study has shown.
Rachel Soon, 01 Sep 2018

MIMS Pharmacist presents an overview of a standardized extract of Pinus pinaster bark, and its potential role in slowing down the progression of diabetic retinopathy.

Dr. Lau Hui Ling, 01 Aug 2017
Oral contraceptive selection should be individualized for each patient to yield maximum benefit.