Most Read Articles
Rachel Soon, 26 Jun 2018

MIMS Pharmacist presents an overview of phosphatidylcholine's physiological role, as well as contemporary research on its pharmacology and effects.

17 Mar 2018
Nonvitamin K antagonist oral anticoagulants (NOAC)-associated intracerebral haemorrhage (ICH) and vitamin K antagonists-ICH appear to have similar ICH volume, haematoma expansion, functional outcome and mortality, results of a recent meta-analysis have shown.
Dr Renly Lim, 01 Aug 2018
Palliative care uses an integrated, multidisciplinary approach to reduce suffering and to improve the quality of life of patients battling with life-threatening illnesses.
03 Mar 2018
Antidepressants, particularly amitriptyline, appear to be effective in improving functional dyspepsia symptoms but not in delaying gastric emptying, a recent study has shown.

Halobetasol propionate with tazarotene effective, safe for psoriasis

22 Jul 2018
Psoriasis affecting the upper limb

Halobetasol propionate plus tazarotene (HP/TAZ) significantly reduces the clinical severity of psoriasis with minimal adverse side effects, a recent study has shown.

The present analysis included data from two randomized, double-blind, multicentre, controlled phase 3 studies, where 418 psoriasis patients (65.1 percent male) were randomly assigned 2:1 to receive HP/TAZ lotion or vehicle control once daily for 8 weeks. The study outcomes included treatment success and safety.

At week 8, 35.8 percent (study 1) and 45.3 percent (study 2) of the participants who received HP/TAZ achieved the primary efficacy outcome of at least a 2-grade improvement in Investigator’s Global Assessment score from baseline. This was significantly higher than in the vehicle control groups (7.0 and 12.5 percent, respectively; p<0.001 for both).

Similarly, at the same time point in study 1 and study 2, significantly more participants in the HP/TAZ vs vehicle control group showed improvements in erythema (44.2 percent and 49.6 percent vs 10.0 percent and 18.7 percent) and plaque elevation (59.3 percent and 59.7 percent vs 17.9 percent and 21.3 percent; p<0.001 for all).

In terms of safety, adverse events were more common in participants who received the HP/TAZ lotion than in those who received the control (35.9 percent vs 21.4 percent). Majority of the adverse events (AEs) were mild or moderate in severity (85.6 percent); only three serious AEs were reported, none of which were related to the HP/TAZ lotion,

The most common treatment-related AEs were contact dermatitis, pruritus and pain the application site.

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Most Read Articles
Rachel Soon, 26 Jun 2018

MIMS Pharmacist presents an overview of phosphatidylcholine's physiological role, as well as contemporary research on its pharmacology and effects.

17 Mar 2018
Nonvitamin K antagonist oral anticoagulants (NOAC)-associated intracerebral haemorrhage (ICH) and vitamin K antagonists-ICH appear to have similar ICH volume, haematoma expansion, functional outcome and mortality, results of a recent meta-analysis have shown.
Dr Renly Lim, 01 Aug 2018
Palliative care uses an integrated, multidisciplinary approach to reduce suffering and to improve the quality of life of patients battling with life-threatening illnesses.
03 Mar 2018
Antidepressants, particularly amitriptyline, appear to be effective in improving functional dyspepsia symptoms but not in delaying gastric emptying, a recent study has shown.