Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
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At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
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Acute ischaemic stroke patients who are current or recent smokers are at greater odds of having unfavourable functional outcomes 3 months after the index event, a study has found.
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Haematological abnormalities bear increased infection risk in rheumatoid arthritis

09 Oct 2019

Rheumatoid arthritis (RA) patients with comorbid anaemia and lymphopenia are at heightened risk of developing common infections, as study has found.

The study included 6,591 individuals (mean age 58.7 years; 67.5 percent female) with newly diagnosed RA. Anaemia was prevalent at diagnosis, detected in 1,066 patients (16.2 percent). Other haematological abnormalities found included neutropenia (n=38; 0.6 percent) and lymphopenia (n=97; 1.5 percent).

RA patients with anaemia and lymphopenia were older than the entire population. Furthermore, those with anaemia tended to be male and had greater comorbidity.

Over a median follow-up of 2.2 years, infection events were recorded in 658 RA patients in the anaemia group, 19 in the neutropenia group, 73 in the lymphopenia group and 3,506 in the no-haematological abnormality group. Crude rates of infection were 181.2, 151.8, 256.4 and 172.0 per 1,000 person-years, respectively.

Lymphopenia and anaemia were associated with heightened infection risk (hazard ratios [HRs], 1.18, 95 percent CI, 1.08–1.29 and 1.37, 1.08–1.73, respectively). There was no evidence of association noted for neutropenia (HR, 0.94, 0.60–1.47).

On further analysis, pneumonia occurred more commonly in RA patients than those without the autoimmune disorder. Influenza vaccination had a protective effect on influenza-like illness in RA patients.

The findings suggest that haematological markers may be used to identify RA patients who might benefit from targeted counselling to stress the importance of early presentation if symptoms of infection develop, according to researchers.

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Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
09 Jan 2020
Acute ischaemic stroke patients who are current or recent smokers are at greater odds of having unfavourable functional outcomes 3 months after the index event, a study has found.
Stephen Padilla, 3 days ago
Brodalumab has exhibited long-term efficacy and consistent safety profile for more than 2 years in the treatment of patients with psoriasis, results of the phase III AMAGINE-2 trial show.