H. pylori infection ups risk of nonalcoholic fatty liver disease
Patients with Helicobacter pylori (H. pylori) infection have a significantly increased risk of nonalcoholic fatty liver disease (NAFLD), results of a recent meta-analysis have shown.
A total of six studies met the eligibility criteria and were included in the meta-analysis. A statistically significant increase in the risk of NAFLD was seen among patients with H. pylori infection (pooled odds ratio [OR], 1.21; 95 percent CI, 1.07–1.37). There was low statistical heterogeneity (I2, 49 percent).
“Further studies are required to clarify how this risk should be addressed in clinical practice,” the investigators said.
Medline and Embase were searched from inception to June 2016 for studies that reported relative risks, ORs or hazard ratios comparing the risk of NAFLD among patients with H. pylori infection vs without H. pylori infection. A random-effect, generic inverse variance method was used to calculate pooled ORs and 95 percent CIs.
“H. pylori is the most common chronic bacterial infection. Patients with H. pylori infection may be at an increased risk of NAFLD because of chronic inflammation and insulin resistance. Several epidemiologic studies attempting to determine this risk have yielded inconsistent results,” the investigators noted.
In a previous systematic review and meta-analysis, researchers found a small but significantly increased risk of NAFLD among participants who had short sleep duration. The risk of NAFLD was significantly higher in participants who had short sleep duration than those with longer sleep duration (pooled risk ratio, 1.19; 1.04–1.36; I2, 0 percent). [J Gastroenterol Hepatol 2016;31:1802-1807]