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6 days ago
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Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
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H. pylori infection ups risk of advanced colorectal neoplasia

14 Sep 2020

Infection with Helicobacter pylori is associated with a higher risk of developing advanced colorectal neoplasia (AN), reports a study. Such correlation is consistent in both serological and histologic assessments of H. pylori infection.

The authors identified a total of 3,753 adults who underwent screening and subsequent surveillance colonoscopies. The development of metachronous AN, as confirmed by surveillance colonoscopy, was the primary outcome.

An H. pylori-specific immunoglobulin G antibody test was used to assess H. pylori infection status. The authors also carried out a sensitivity analysis by H. pylori infection status based on histology.

During a median follow-up of 41 months, AN incidence stood at 3.2 percent in participants with H. pylori infection and 1.7 percent in those without.

Multivariable analysis adjusted for age, body mass index, smoking status, alcohol intake, family history of colorectal cancer, and baseline adenoma characteristics revealed a 74-percent increased risk for metachronous AN in participants with H. pylori seropositivity (adjusted hazard ratio [aHR], 1.74, 95 percent confidence interval [CI], 1.11–2.73) compared with those without.

This association agreed with H. pylori infection status based on histology (aHR, 3.51, 95 percent CI, 1.64–7.51). Moreover, subgroup analysis showed a positive association in both no-adenoma and adenoma removal subgroups.

“An association between H. pylori infection and colorectal neoplasia has [also] been reported in cross-sectional studies,” the authors said.

“Prospective studies are necessary to determine whether H. pylori eradication can reduce the risk of colorectal neoplasia,” they added.

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Most Read Articles
6 days ago
Regular practice of yoga postures confers benefits for glucose control, oxidative stress, inflammatory response, and sleep quality in patients with type 2 diabetes, a study has found.
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
09 Jan 2021
Women with central adiposity, regardless of menopausal status, are at risk of developing breast cancer, according to a study.