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Jairia Dela Cruz, 5 days ago
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
Pearl Toh, 19 hours ago
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Yesterday
Women with pre-eclampsia are at higher risk of developing heart failure, a study suggests.
06 Sep 2020
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H. pylori infection ups risk of advanced colorectal neoplasia

14 Sep 2020

Infection with Helicobacter pylori is associated with a higher risk of developing advanced colorectal neoplasia (AN), reports a study. Such correlation is consistent in both serological and histologic assessments of H. pylori infection.

The authors identified a total of 3,753 adults who underwent screening and subsequent surveillance colonoscopies. The development of metachronous AN, as confirmed by surveillance colonoscopy, was the primary outcome.

An H. pylori-specific immunoglobulin G antibody test was used to assess H. pylori infection status. The authors also carried out a sensitivity analysis by H. pylori infection status based on histology.

During a median follow-up of 41 months, AN incidence stood at 3.2 percent in participants with H. pylori infection and 1.7 percent in those without.

Multivariable analysis adjusted for age, body mass index, smoking status, alcohol intake, family history of colorectal cancer, and baseline adenoma characteristics revealed a 74-percent increased risk for metachronous AN in participants with H. pylori seropositivity (adjusted hazard ratio [aHR], 1.74, 95 percent confidence interval [CI], 1.11–2.73) compared with those without.

This association agreed with H. pylori infection status based on histology (aHR, 3.51, 95 percent CI, 1.64–7.51). Moreover, subgroup analysis showed a positive association in both no-adenoma and adenoma removal subgroups.

“An association between H. pylori infection and colorectal neoplasia has [also] been reported in cross-sectional studies,” the authors said.

“Prospective studies are necessary to determine whether H. pylori eradication can reduce the risk of colorectal neoplasia,” they added.

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Most Read Articles
Jairia Dela Cruz, 5 days ago
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
Pearl Toh, 19 hours ago
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Yesterday
Women with pre-eclampsia are at higher risk of developing heart failure, a study suggests.
06 Sep 2020
Type 2 diabetes mellitus patients taking proton pump inhibitors (PPIs) are at a higher risk of sustaining hip fractures, a recent study has found.