Most Read Articles
Dr. Joseph Delano Fule Robles, 14 Nov 2017

A recent study conducted by The University of Hong Kong (HKU) revealed that long-term use of proton pump inhibitors (PPIs) is associated with a significantly increased risk of gastric cancer even in patients who have had Helicobacter pylori eradicated. 

14 Nov 2017
The 5-year survival rates for human papillomavirus (HPV)-associated cancers vary greatly according to age and race, with Caucasians and younger patients tending to have better survival, according to a recent US study.
6 days ago
Both hatha yoga and a low-FODMAP (Fermentable, Oligo-, Di-, Monosaccharides and Polyol) diet can alleviate gastrointestinal symptoms, as well as improve a range of other psychological and physiological health parameters, in patients with irritable bowel syndrome (IBS), a study has shown.
6 days ago
Men with breast cancer have tumours that are typically of the human epidermal growth factor receptor 2-negative Luminal B subtype and positive for oestrogen receptor, progesterone receptor and androgen receptor, according to the results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program study.

H. pylori infection, HbA1c levels increase colorectal adenoma risk

10 Sep 2017
Although the prevalence for perforation during colonoscopy is small, patients should not neglect the underlying medical risks.

The combination of Helicobacter pylori infection and elevated haemoglobin A1c (HbA1c) levels is likely to increase the risk of colon adenoma, a recent study suggests.

Researchers conducted a cross-sectional, retrospective study at the MacKay Memorial Hospital in Taiwan to investigate the interaction between H. pylori and hyperglycaemia status on the risk of colon adenoma.

A total of 3,943 participants aged >40 years undergoing bidirectional gastrointestinal endoscopy on the same day between July 2006 and June 2015 were included. All patients had a gastric biopsy specimen tested for H. pylori. The main outcome was colon adenoma with and without H. pylori infection at different HbA1c levels.

The prevalence of colorectal adenomas was 37.3 percent in patients who were H. pylori‒positive and 27.29 percent in those who were H. pylori‒negative. Age, male sex, body mass index, H. pylori infection and HbA1c ≥6.5 percent were independent risk factors for adenoma based on multivariable logistic regression analysis. This risk was reduced with the use of hypoglycaemic agents.

HbA1c levels, regardless of H. pylori status, increased the prevalence of adenoma. For patients with H. pylori, the odds ratio (OR) for adenoma was 1.44 (95 percent CI, 1.20 to 1.73), whereas those without H. pylori but had HbA1c ≥7.0 percent had an OR of 1.68 (1.05 to 2.70). If both conditions were present, the OR was 4.79 (2.92 to 7.84).

A 1-percent increase in HbA1c correlated with an increased prevalence of adenoma by 42.4 percent in H. pylori‒positive patients.

“Both H. pylori and type 2 diabetes mellitus are possible risk factors for colon adenoma,” researchers said.

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Most Read Articles
Dr. Joseph Delano Fule Robles, 14 Nov 2017

A recent study conducted by The University of Hong Kong (HKU) revealed that long-term use of proton pump inhibitors (PPIs) is associated with a significantly increased risk of gastric cancer even in patients who have had Helicobacter pylori eradicated. 

14 Nov 2017
The 5-year survival rates for human papillomavirus (HPV)-associated cancers vary greatly according to age and race, with Caucasians and younger patients tending to have better survival, according to a recent US study.
6 days ago
Both hatha yoga and a low-FODMAP (Fermentable, Oligo-, Di-, Monosaccharides and Polyol) diet can alleviate gastrointestinal symptoms, as well as improve a range of other psychological and physiological health parameters, in patients with irritable bowel syndrome (IBS), a study has shown.
6 days ago
Men with breast cancer have tumours that are typically of the human epidermal growth factor receptor 2-negative Luminal B subtype and positive for oestrogen receptor, progesterone receptor and androgen receptor, according to the results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program study.