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21 Nov 2020
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Roshini Claire Anthony, 13 Nov 2020

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Vitamin D deficiency may be a contributing factor to the mortality rate among patients with the novel coronavirus disease (COVID-19), reports a new study.

H. pylori-eradication therapy improves insulin sensitivity, hepatic steatosis in NAFLD

13 Jan 2020

Helicobacter pylori-eradication therapy (HPET) in patients with nonalcoholic fatty liver disease (NAFLD) leads to greater improvement in homeostasis model assessment-insulin resistance (HOMA-IR) but exerts comparable effects on hepatic steatosis and liver enzymes as compared with diet and exercise alone, a study has shown.

The trial included 80 NAFLD patients with H. pylori coinfection, 36 of which were assigned to receive standard management therapy (SMT; diet and exercise) and 44 to HPET (SMT plus amoxicillin, clarithromycin and pantoprazole).

A total of 28 patients in the SMT group and 36 in the HPET group were included in a modified intention-to-treat population. At week 24, controlled attenuation parameter (CAP) scores significantly decreased in the two groups (p=0.002 and p<0.001, respectively), without significant between-group difference (p=0.213).

H. pylori infection was successfully eradicated in 68 percent of patients in the HPET group. This group of patients showed greater improvement in HOMA-IR at week 24 compared to nonresponders or those treated with SMT (p=0.007).

There were also significant reductions observed in liver enzymes in both groups, although the changes between them were similar. Meanwhile, lipid parameters remained stable at week 24 . The HPET group exhibited a significant increase in the levels of reduced glutathione, but the change was not statistically different relative to the SMT group.

More studies involving a larger sample size, more effective HPET regimen and paired liver biopsy are needed for improved understanding, the researchers said.

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Most Read Articles
21 Nov 2020
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
6 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

3 days ago
Vitamin D deficiency may be a contributing factor to the mortality rate among patients with the novel coronavirus disease (COVID-19), reports a new study.