Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Guiding therapy by coronary CTA better than standard care alone in patients with angina

24 Oct 2019

Coronary computed tomography angiography (CTA) is consistently effective in reducing the rate of death from coronary heart disease (CHD) or nonfatal myocardial infarction (MI) across subgroups in patients with stable chest pain, as shown in a recent study, noting plausible underlying mechanisms.

A total of 4,146 participants were randomly assigned to either standard care alone or standard care plus coronary CTA. The primary endpoint of death from CHD or nonfatal MI was explored by symptoms, diagnosis, coronary revascularizations and preventive strategies. This open-label trial assessed the consistency and mechanisms of the 5-year reduction in this endpoint.

There were consistent event reductions across symptom and risk categories (p-interaction=NS). Coronary CTA resulted in a decreased incidence rate of the primary endpoint (0.23, 95 percent CI, 0.13–0.35 vs 0.59, 0.42–0.80 per 100 patient-years; p<0.001) in patients who were not diagnosed with angina due to CHD.

Patients who had undergone coronary CTA had higher rates of coronary revascularization in the first year (hazard ratio [HR], 1.21, 1.01–1.46; p=0.042) but lower beyond 1 year (HR, 0.59, 0.38–0.90; p=0.015). Rates of preventive therapies throughout follow-up (p-all<0.001) were also higher in patients assigned to coronary CTA, with rates highest in those with CT-defined coronary artery disease.

In addition, modeling studies exhibited the plausibility of the observed effect size.

“Coronary CTA improves coronary heart disease outcomes by enabling better targeting of preventative treatments to those with coronary artery disease,” the investigators said.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.