Most Read Articles
Tristan Manalac, 09 Oct 2019
Shorter courses of dual antiplatelet therapy do not perform worse than longer regimens, according to a recent study presented at the 31st Transcatheter Cardiovascular Therapeutics scientific symposium (TCT 2019).
Christina Lau, 17 Sep 2019

Significant therapeutic gaps exist in LDL-cholesterol (LDL-C) management among patients with high cardiovascular (CV) risk in Hong Kong, according to two studies reported at the European Society of Cardiology (ESC) Congress 2019 and World Congress of Cardiology (WCC) 2019.

23 Oct 2019
Implementing a high-sensitivity cardiac troponin I assay with sex-specific diagnostic thresholds results in identifying five times more women than men with myocardial injury, reports a study.

Guideline-directed medical therapy underused in elderly HF patients

12 Mar 2020
Guideline-directed medical therapy (GDMT) is underused in elderly patients with heart failure with reduced ejection fraction (HFrEF), registry data have shown.

Among patients with HFrEF aged 65 years in the Korean Acute Heart Failure (KorAHF) registry, only 43.8 percent were treated with both beta-blockers and renin-angiotensin system (RAS) inhibitors. The use of GDMT decreased with increasing age and was mainly attributable to decreased prescription of beta-blockers. [BMJ Open 2020, doi: 10.1136/bmjopen-2019-030514]

Similarly, data from the CHECK-HF registry showed that only 29.9 percent of HFrEF patients aged ≥80 years were treated with a beta-blocker, a RAS inhibitor and a mineralocorticoid receptor antagonist (MRA), and only 43.8 percent of the patients received ≥50 percent of the target doses of triple therapy. According to the investigators, comorbidities and reported contraindications or intolerance (beta-blockers, 3.5 percent; RAS inhibitors, 7.2 percent; MRAs, 6.1 percent) did not fully explain the underuse of recommended HF therapies. [Clin Res Cardiol 2020, doi: 10.1007/s00392-020-01607-y]

In the Korean study, GDMT use was associated with a significant 53 percent reduction in risk of all-cause mortality vs no GDMT.
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Most Read Articles
Tristan Manalac, 09 Oct 2019
Shorter courses of dual antiplatelet therapy do not perform worse than longer regimens, according to a recent study presented at the 31st Transcatheter Cardiovascular Therapeutics scientific symposium (TCT 2019).
Christina Lau, 17 Sep 2019

Significant therapeutic gaps exist in LDL-cholesterol (LDL-C) management among patients with high cardiovascular (CV) risk in Hong Kong, according to two studies reported at the European Society of Cardiology (ESC) Congress 2019 and World Congress of Cardiology (WCC) 2019.

23 Oct 2019
Implementing a high-sensitivity cardiac troponin I assay with sex-specific diagnostic thresholds results in identifying five times more women than men with myocardial injury, reports a study.