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Growth hormone therapy does not elevate mortality in children with growth disorder

29 Sep 2017

Paediatric growth hormone (GH) treatment does not increase mortality in children with idiopathic GH deficiency, idiopathic short stature, Turner syndrome, short stature homeobox-containing gene (SHOX) deficiency, history of benign neoplasia or born small for gestational age, suggests a recent study.

However, there is an increase in mortality among children with prior malignancy and those with underlying serious non-GH-deficient medical conditions.

A prospective, multinational, observational study was conducted on children with growth disorders from 827 study sites in 30 countries to investigate mortality in children receiving GH treatment. The main outcome measures were standardized mortality ratios (SMRs) and 95 percent CIs using age- and sex-specific rates from the general population.

A total of 9,504 GH-treated patients were followed for ≥4 years (67,163 person-years of follow-up). Of these, 42 deaths were reported (SMR, 0.77; 95 percent CI, 0.56 to 1.05).

Patients with history of malignant neoplasia had significantly elevated SMR (6.97; 3.81 to 11.69), and those with other serious non-GH-deficient conditions had borderline elevated SMR (2.47; 0.99 to 5.09).

Children with history of benign neoplasia (SMR, 1.44; 0.17 to 5.20), idiopathic GH deficiency (SMR, 0.11; 0.02 to 0.33), idiopathic short stature (SMR, 0.20; 0.01 to 1.10), short stature associated with small for gestational age birth (SMR, 0.66; 0.08 to 2.37), Turner syndrome (SMR, 0.51; 0.06 to 1.83) or SHOX gene deficiency (SMX, 0.83; 0.02 to 4.65) had no elevated SMRs.

“Although paediatric growth hormone treatment is generally considered safe for approved indications, concerns have been raised regarding potential for increased risk of mortality in adults treated with GH during childhood,” according to researchers.

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Most Read Articles
Stephen Padilla, 28 Nov 2017
A dietary pattern rich in fresh and dried fruits, nuts and seeds, vegetable oils, and low-fat dairy products appears to lower the incidence rate of insulin resistance, according to an Iran study.
05 Oct 2017
Older men and women taking whey-protein drinks show a load-dependent slowing of gastric emptying and altered gut hormone secretion compared with controls, a recent study has found. However, whey protein does not appear to suppress subsequent ad libitum energy intake.