Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, 2 days ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, 2 days ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
6 days ago
In type 2 diabetes patients taking sulfonylureas, hypoglycaemia duration is longer at night and is inversely correlated with the level of glycated haemoglobin (HbA1c), a new study reports.

Greater insulin resistance tied to increased BMD, but not fracture risk

13 Jul 2019

An association exists between greater insulin resistance (IR) and higher bone mineral density (BMD) in nondiabetic older adults, but evidence for an increased fracture risk with greater IR is inconsistent, a recent study has found.

The homeostatic model assessment (HOMA) of IR quartiles had cutoff values of 1.05, 1.54 and 2.33. The fourth HOMA-IR quartile showed 0.104-g/cm2 higher total hip BMD than the first quartile (p<0.001). Adjustment made for body mass index (BMI) attenuated this difference (adjusted mean difference, 0.007 g/cm2; p=0.371).

Unadjusted models showed a lower fracture risk in participants with higher HOMA-IR (third quartile: hazard ratio [HR], 0.86, 95 percent CI, 0.73–1.01; fourth quartile: HR, 0.65, 0.47–0.89, as compared with the first quartile).

However, fracture risk became significantly greater in the third quartile (HR, 1.19, 1.00–1.41) and slightly higher in the fourth quartile (HR, 1.12, 0.87–1.46) compared with the first quartile when adjustments were made for BMD and BMI.

“In contrast to the relationship between type 2 diabetes (T2D) and fracture risk, we did not find consistent evidence that greater IR is associated with increased fracture risk after adjustment for BMI and BMD,” the investigators said.

This study examined the relationship among HOMA-IR, BMD and incident nonspine fractures in 2,398 community-dwelling, nondiabetic older adults (mean age, 74±3 years; 53 percent women; 38 percent black) in the Health, Aging and Body Composition Prospective Cohort Study (median follow-up, 12 years).

“Adults with T2D have higher fracture risk compared with nondiabetics, despite having higher BMD,” the investigators said. “IR has been associated with increased BMD.”

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Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, 2 days ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, 2 days ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
6 days ago
In type 2 diabetes patients taking sulfonylureas, hypoglycaemia duration is longer at night and is inversely correlated with the level of glycated haemoglobin (HbA1c), a new study reports.