Gout may increase risk of developing erectile dysfunction
Gout appears to elevate the risk of developing erectile dysfunction (ED), suggesting a potential role for hyperuricaemia and inflammation as independent risk factors for ED, according to a study.
A total of 2,290 new ED cases were identified among 38,438 patients with gout (mean age 63.6 years) and 8,447 cases among 154,332 individuals in the comparison cohort over a 5-year median follow-up (11.9 vs 10.5 per 1,000 person-years, respectively).
Among gout patients, the univariate (matched for age, entry time and body mass index [BMI]) hazard ratio (HR) for ED was 1.13 (95 percent CI, 1.08–1.19) and the multivariate HR was 1.15 (1.09–1.21). By restricting gout cases to those receiving antigout treatment (n=27,718), the magnitude of relative risk was stronger in the sensitivity analysis than the primary analysis (multivariate HR, 1.31; 1.23–1.39).
This cohort study used The Health Improvement Network, an electronic medical record database in the UK. Each case of incident gout was matched to up to five individuals without gout by age, enrolment time and BMI. The authors calculated the multivariate HR for ED after adjusting for smoking, alcohol consumption, comorbidities and medication use.
A previous study found that gout might be independently associated with an increased risk of diabetes, with the magnitude of association being larger in women than in men. On the other hand, another study reported an inverse association between gout and the risk of developing Alzheimer’s disease. [Ann Rheum Dis 2016;75:91-95; Ann Rheum Dis 2016;75:547-551]
“Gout is the most common inflammatory arthritis. ED is common in the general population; however, evidence regarding ED among patients with gout is limited,” the authors noted.