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01 Dec 2020
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Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Tristan Manalac, Yesterday
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Good sleep needed to maintain optimal nutritional status in older adults

15 Dec 2020

Sleep disorders usually go hand in hand with malnutrition in older adults, according to a study, highlighting the importance that this population get good sleep quality and sufficient amount of it in order to maintain good nutritional status.

The study included 6,792 community-dwelling adults (mean age, 62.4 years; 62.5 percent women) from the West China Health and Aging Trend (WCHAT) study. Of these, 3,201 (47.1 percent) were considered poor sleepers, having Pittsburgh Sleep Quality Index (PSQI) scores >5, and 1,831 (27.0 percent) were at risk of malnutrition according to the Mini Nutritional Assessment Short Form (MNA-SF scores <12).

Compared with well-nourished participants, those at risk of malnutrition tended to have poor sleep quality (p<0.05), reporting either few or long sleep hours (<6 hours or ≥9 hours; p<0.05). The latter were also more likely to be older, female, single, and have greater chronic diseases burden (at least two).

Multivariable logistic regression model adjusted for potential confounders showed that the likelihood that participants with poor sleep quality were at risk of malnutrition was 1.6 times greater than those who had good sleep quality (odds ratio [OR], 1.62, 95 percent confidence interval [CI], 1.44–1.82).

Furthermore, short and long sleep durations were also confirmed to be associated with malnutrition risk (<6 hours: OR, 1.42, 95 percent CI, 1.16–1.73; >9 hours: OR, 1.24, 95 percent CI, 1.05–1.47).

Although unclear, several possible mechanisms could justify the association between sleep disorders and nutritional status. First, sleep deprivation ups total daily energy expenditure, which then drops during recovery sleep. In older adults, increased energy expenditure may increase the risk of malnutrition. [J Physiol 2011;589:235-244]

Furthermore, sleep disturbances heighten the expression of circulating inflammatory cytokines, such as C-reactive protein, interleukin-6, and tumour necrosis factor-α. Persistent inflammatory status, in turn, promotes malnutrition through increased resting energy expenditure and muscle catabolism. [Biol Psychiatry 2016;80:40-52; J Parenter Enteral Nutr 2015;39:56-62]

Lastly, sleep disorders may adversely affect appetite and dietary quality. [J Nutr Health Aging 2020;24:152-159; J Clin Nurs 2016;25:1703-1712; Appetite 2020;153:104748]

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Tristan Manalac, Yesterday
While antibody titres against SARS-CoV-2 wane with time, the immune system is capable of producing memory B-cells that can last for at least 6 months after infection, suggesting that the body will be able to protect itself in the case of re-exposure, according to a new study.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.