Most Read Articles
Roshini Claire Anthony, 11 Dec 2020

Treatment with the nonsteroidal, selective mineralocorticoid receptor antagonist finerenone reduced chronic kidney disease (CKD) progression and cardiovascular (CV) event risk in patients with CKD and type 2 diabetes (T2D), according to the FIDELIO-DKD* study presented at ASN Kidney Week 2020.

Stephen Padilla, 22 Jun 2020
A dietary pattern (DP) characterized by high intakes of eggs, fish, milk, and other dairy products appears to confer protective benefits against incident cardiovascular disease (CVD) in women, reveals a study.

Good midterm outcomes seen in congenital heart disease-related PAH

17 Sep 2020

Patients with congenital heart disease-associated pulmonary artery hypertension (CHD-PAH) have favourable midterm outcomes, a new study reports.

Researchers established a multi-centre prospective registry called the TACHYON*, which included nine paediatric cardiology centres. The present study included 87 CHD-PAH patients (mean age, 37.4±18.2 years), from whom relevant clinical and laboratory data were collected every 3 months for the first year, and once per year thereafter.

Over a mean follow-up duration of 23.9 months, nine patients needed to be admitted more than once for cardiopulmonary reasons, and five died. The 2-year Kaplan-Meier survival rate was 93.2 percent, while the hospitalization-free survival rate over the same time span was 91.8 percent.

The researchers then assessed the value of three noninvasive parametersfunctional class, the 6-minute walk distance (6MWD), and N-terminal pro-brain natriuretic peptide (NT-pro BNP)/BNPin predicting adverse outcomes during follow-up.

They found that survival and hospitalization-free survival rates were not statistically different between patients with any number of low-risk findings in any of the three parameters. However, the total number of high-risk findings held significant predictive value. Those with zero high-risk noninvasive findings had significantly better 2-year total (p=0.002) and cardiopulmonary hospitalization-free (p=0.005) survival rates.

Notably, adherence of physicians to the European Society of Cardiology (ESC) guidelines for CHD-PAH follow-up was low. The registration rate of cardiopulmonary exercise testing (CPET) was very low, at 3 percent, and only 14 percent of patients were made to undergo repeat cardiac catheterization.

*Taiwan congenital heart disease associated with pulmonary arterial hypertension

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Most Read Articles
Roshini Claire Anthony, 11 Dec 2020

Treatment with the nonsteroidal, selective mineralocorticoid receptor antagonist finerenone reduced chronic kidney disease (CKD) progression and cardiovascular (CV) event risk in patients with CKD and type 2 diabetes (T2D), according to the FIDELIO-DKD* study presented at ASN Kidney Week 2020.

Stephen Padilla, 22 Jun 2020
A dietary pattern (DP) characterized by high intakes of eggs, fish, milk, and other dairy products appears to confer protective benefits against incident cardiovascular disease (CVD) in women, reveals a study.