Most Read Articles
29 Mar 2020
Targeting a low-density lipoprotein cholesterol level <70 mg/dL following an ischaemic stroke of atherosclerotic origin helps to avoid one in four subsequent major vascular events without increasing the risk of intracranial haemorrhage over about 5 years of follow-up, according to data from the Treat Stroke to Target trial.
Pearl Toh, 12 Sep 2020
Early initiation of rhythm-control therapy led to a significantly reduced risk of major adverse cardiovascular (CV) outcomes compared with usual care (typically rate control) in patients with newly diagnosed atrial fibrillation (AF) at risk of stroke, reveals the EAST-AFNET 4* trial presented at ESC 2020.
Audrey Abella, 16 Sep 2020
The final results of EVAPORATE* reinforce the plaque-regressing potential of icosapent ethyl (IPE) in patients on statins for elevated triglycerides.
01 Feb 2020
High-intensity statin therapy appears to be seeing increased use in patients with acute coronary syndrome and leads to better lipid control, according to a recent Thailand study.

Good midterm outcomes seen in congenital heart disease-related PAH

17 Sep 2020

Patients with congenital heart disease-associated pulmonary artery hypertension (CHD-PAH) have favourable midterm outcomes, a new study reports.

Researchers established a multi-centre prospective registry called the TACHYON*, which included nine paediatric cardiology centres. The present study included 87 CHD-PAH patients (mean age, 37.4±18.2 years), from whom relevant clinical and laboratory data were collected every 3 months for the first year, and once per year thereafter.

Over a mean follow-up duration of 23.9 months, nine patients needed to be admitted more than once for cardiopulmonary reasons, and five died. The 2-year Kaplan-Meier survival rate was 93.2 percent, while the hospitalization-free survival rate over the same time span was 91.8 percent.

The researchers then assessed the value of three noninvasive parametersfunctional class, the 6-minute walk distance (6MWD), and N-terminal pro-brain natriuretic peptide (NT-pro BNP)/BNPin predicting adverse outcomes during follow-up.

They found that survival and hospitalization-free survival rates were not statistically different between patients with any number of low-risk findings in any of the three parameters. However, the total number of high-risk findings held significant predictive value. Those with zero high-risk noninvasive findings had significantly better 2-year total (p=0.002) and cardiopulmonary hospitalization-free (p=0.005) survival rates.

Notably, adherence of physicians to the European Society of Cardiology (ESC) guidelines for CHD-PAH follow-up was low. The registration rate of cardiopulmonary exercise testing (CPET) was very low, at 3 percent, and only 14 percent of patients were made to undergo repeat cardiac catheterization.

*Taiwan congenital heart disease associated with pulmonary arterial hypertension

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Most Read Articles
29 Mar 2020
Targeting a low-density lipoprotein cholesterol level <70 mg/dL following an ischaemic stroke of atherosclerotic origin helps to avoid one in four subsequent major vascular events without increasing the risk of intracranial haemorrhage over about 5 years of follow-up, according to data from the Treat Stroke to Target trial.
Pearl Toh, 12 Sep 2020
Early initiation of rhythm-control therapy led to a significantly reduced risk of major adverse cardiovascular (CV) outcomes compared with usual care (typically rate control) in patients with newly diagnosed atrial fibrillation (AF) at risk of stroke, reveals the EAST-AFNET 4* trial presented at ESC 2020.
Audrey Abella, 16 Sep 2020
The final results of EVAPORATE* reinforce the plaque-regressing potential of icosapent ethyl (IPE) in patients on statins for elevated triglycerides.
01 Feb 2020
High-intensity statin therapy appears to be seeing increased use in patients with acute coronary syndrome and leads to better lipid control, according to a recent Thailand study.