Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
2 days ago
Among patients with moderate-to-severe psoriasis, the use of biologics appears to lower the risk of being hospitalized for the novel coronavirus disease (COVID-19), a new study has found.

Good cholesterol factors in virus clearance time in COVID-19

20 Dec 2020

For some COVID-19 patients, virus clearance takes more than half a month, a study has found. Risk factors for prolonged clearance include low high-density lipoprotein cholesterol (HDL-C) levels, as well as liver damage and hyperglycaemia.

The study included 115 COVID-19 patients (mean age, 60.5 years; 53 percent male) with SARS-COV-2 nucleic acid positive time exceeding 14 days. Most patients presented with fever (80.9 percent) and had comorbidities (65.2 percent), including hypertension (n=23), diabetes (n=22), or both (n=11).

A total of 101 patients had severe COVID-19 infection (87.8 percent), and eight had the critical type (7.0 percent). In terms of antiviral drugs, 63 patients (54.8 percent) received arbidol, 43 (37.4 percent) were given lopinavir/ritonavir, five (4.3 percent) were on other drugs, and four (3.5 percent) did not receive treatment. Antibiotics, on the other hand, were given in the majority of the population: 59 patients (51.3 percent) received one while 16 (13.9 percent) received two or more. Glucocorticoid was used in 14 patients (12.2 percent), while Chinese traditional medicine was given in 105 patients (91.3 percent).

Overall, nucleic acid turned negative a mean of 32.5 days after the onset of symptoms. Viral clearance time was longer in the no-fever vs fever group, in the diabetes vs no-comorbidity group, among patients with elevated levels of alanine aminotransferase (ALT) or fasting blood glucose (GLU), and among those with lower levels of albumin (ALB) or HDLC (p<0.05).

In multivariate Cox regression models, risk factors for prolonged viral clearance included ALT (odds ratio [OR], 2.164, 95 percent confidence interval [CI], 1.276–3.670; p=0.004), GLU (OR, 2.064, 95 percent CI, 1.195–3.566; p=0.009), and HDLC (OR, 0.527, 95 percent CI, 0.307–0.907; p=0.021).

Given the findings, clinicians should look out for COVID-19 patients with dyslipidemia.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
2 days ago
Among patients with moderate-to-severe psoriasis, the use of biologics appears to lower the risk of being hospitalized for the novel coronavirus disease (COVID-19), a new study has found.