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Roshini Claire Anthony, Yesterday

Patients undergoing chemotherapy for breast or haematological cancers could potentially reduce their risk of chemotherapy-related cardiotoxicity with the use of angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists (ARBs), or beta-blockers as primary prevention, according to a systematic review and meta-analysis presented at the recent EuroEcho 2019 conference.

6 days ago
Men who undergo flexible cystoscopy, particularly with a longer dwell time, may benefit from intraurethral lidocaine as it provides significant pain reduction, suggest the results of a meta-analysis. Evidence is lacking for other tested interventions.
Tristan Manalac, 2 days ago
Users of electronic nicotine delivery systems are likely to have received a diagnosis of clinical depression in the past, according to a recent study.
Pearl Toh, 6 days ago
Getting just under one extra hour of sleep per night can go a long way for the health of college students, who are often sleep-deprived, a study suggests.

Gluten-free diet remains a strong treatment option for dermatitis herpetiformis

29 Sep 2019

Majority of patients with dermatitis herpetiformis (DH) are unable to regain gluten tolerance, a recent study has shown. A lifelong gluten-free diet (GFD) therefore remains warranted as a treatment option.

Researchers performed a gluten challenge on 19 DH patients (mean age, 58 years; 13 males) who had been adhering to a GFD for a mean of 23 years. The challenge involved daily consumption of 200 g of commercially available wheat bread for 3 days. Skin and small-bowel biopsies were obtained before and after the gluten challenge to assess DH and/or coeliac disease manifestations.

After the gluten challenge, 15 patients experienced rashes over a mean of 5.6 months, corresponding to an incidence rate of 79 percent. At postchallenge, 12 showed small-bowel mucosal atrophy and 10 had serum samples enriched with antibodies targeting transgutaminase (TG) 2.

Moreover, two patients who had no rashes developed high levels of immunoglobulin (Ig) A-class TG-2 targeted antibodies and had to discontinue the gluten challenge at 4 months. One other patient with no rashes showed villous atrophy upon small bowel biopsy at 12 months. Therefore, a total of 18 patients experienced relapse, with an overall rate of 95 percent.

Only one patient did not relapse, showing normal skin and gastrointestinal symptoms throughout the challenge period, as well as having normal biopsy findings. As expected, the prechallenge biopsies did not exhibit rashes nor IgA and TG3 deposits.

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Most Read Articles
Roshini Claire Anthony, Yesterday

Patients undergoing chemotherapy for breast or haematological cancers could potentially reduce their risk of chemotherapy-related cardiotoxicity with the use of angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists (ARBs), or beta-blockers as primary prevention, according to a systematic review and meta-analysis presented at the recent EuroEcho 2019 conference.

6 days ago
Men who undergo flexible cystoscopy, particularly with a longer dwell time, may benefit from intraurethral lidocaine as it provides significant pain reduction, suggest the results of a meta-analysis. Evidence is lacking for other tested interventions.
Tristan Manalac, 2 days ago
Users of electronic nicotine delivery systems are likely to have received a diagnosis of clinical depression in the past, according to a recent study.
Pearl Toh, 6 days ago
Getting just under one extra hour of sleep per night can go a long way for the health of college students, who are often sleep-deprived, a study suggests.