Most Read Articles
25 Aug 2015
At the Northern Pharmacists Convention cum 48th Malaysian Pharmaceutical Society Seminar 2015 held recently at Bayview Beach Hotel, Penang, Sanofi invited three distinguished speakers – Dr Khaw Chong Hui, Dr Lo Kang Shang Chit, and Professor Dr Karl-Josef Gundermann – to speak on the importance of renal protection in managing diabetic hypertension, the use of antihistamines in managing chronic urticaria (CU), and the role of essential phospholipids (EPL) in fatty liver diseases, respectively.
Roshini Claire Anthony, 07 Nov 2017

Women who are underweight, particularly in their late teens and mid-thirties, may be at risk for early menopause, a recent study found. 

16 Aug 2014

New drug applications approved by US FDA as of 15-30 Aug which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Audrey Abella, 20 Jan 2017
Diabetes was not a risk factor for total knee replacement (TKR) due to severe knee osteoarthritis, a Singapore study found.

Gluten-free diet delays insulin dose increase in T1D

Elaine Soliven
18 Sep 2017

A gluten-free diet (GFD) may help delay the increase of insulin dose in children with newly diagnosed type 1 diabetes (T1D), according to a study presented at EASD 2017.

The researchers retrospectively analysed the changes in insulin dose in 46 children diagnosed with T1D (mean age at diagnosis, 6.9 years), 42 of whom also had coeliac disease (CD) and were on a GFD. Participants were divided into two groups: GFD+ (n=27; started GFD before or since the diagnosis of T1D) and GFD- (n=19; started GFD few years after the diagnosis of T1D or those not keeping GFD). Patients were followed up for up to 3 years. [EASD 2017, abstract 1215]

At 1-year follow-up, a significant increase in insulin dose was observed in the GFD- group compared with the GFD+ group (0.64 vs 0.43 IU/kg; p<0.01). At 1.5-years follow-up, children in the GFD- group still had higher insulin dose than those in the GFD+ group (0.7 vs 0.5 IU/kg; p<0.01).

A significant increase in insulin dose was only noted in the GFD+ group after 2 years of follow-up.

Overall, both groups showed a similar increase in insulin dose at 3 years, from 0.40 to 0.72 IU/kg in the GFD- group (p<0.001) and from 0.41 to 0.71 IU/kg in the GFD+ group (p<0.001).

“During the remission phase, the increase in insulin requirement reflects the evolution of endogenous insulin reserve. GFD, therefore, likely helps to conserve endogenous insulin … The prolongation of the remission phase is of clinical significance in view of the long-term metabolic control,” according to lead author Dr Peter Toth-Heyn from the First Department of Pediatrics at Semmelweis University in Budapest, Hungary.

“These are the first clinical data confirming the possible pathogenetic role of gluten in the progression of T1D,” said Toth-Heyn. “[However,] there is not enough clinical evidence to prove a role for GFD in T1D prevention.”
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Most Read Articles
25 Aug 2015
At the Northern Pharmacists Convention cum 48th Malaysian Pharmaceutical Society Seminar 2015 held recently at Bayview Beach Hotel, Penang, Sanofi invited three distinguished speakers – Dr Khaw Chong Hui, Dr Lo Kang Shang Chit, and Professor Dr Karl-Josef Gundermann – to speak on the importance of renal protection in managing diabetic hypertension, the use of antihistamines in managing chronic urticaria (CU), and the role of essential phospholipids (EPL) in fatty liver diseases, respectively.
Roshini Claire Anthony, 07 Nov 2017

Women who are underweight, particularly in their late teens and mid-thirties, may be at risk for early menopause, a recent study found. 

16 Aug 2014

New drug applications approved by US FDA as of 15-30 Aug which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Audrey Abella, 20 Jan 2017
Diabetes was not a risk factor for total knee replacement (TKR) due to severe knee osteoarthritis, a Singapore study found.