Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Jairia Dela Cruz, 3 days ago
Nonsmall cell lung cancer (NSCLC) patients harbouring sensitive EGFR mutations may fare well with the third-generation tyrosine kinase inhibitor osimertinib as an upfront therapy, with the results of a network meta-analysis showing that the drug tops other currently available options in terms of progression-free survival and tolerability.
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.

Glucose variability affects CABG outcomes

10 Sep 2019

Glucose variability predicts poor outcomes after coronary artery bypass grafting (CABG), a recent study has found.

Researchers conducted a prospective observational study on 137 nondiabetic patients (mean age, 64.45±9.22 years; 67.9 percent male) who underwent CABG. Blood glucose was measured at 72 hours after the procedure and was used in the computation of glucose variability. Study outcomes included the duration of stay in the ICU, length of hospital stay, arrhythmia and mechanical ventilation time.

Majority of the participants had glucose levels 7.00 mmol/L and were identified as having hyperglycaemia (n=126; mean age, 64.88±8.98; 66.7 percent male). The remaining 11 patients were euglycaemic (mean age, 59.63±10.94 years; 81.8 percent male). Most participants also had abnormal glucose variability, with mean of daily difference (MODD) ≥1.40 mmol/L.

Compared with patients who had normal MODD, those with abnormal glucose variability were in the ICU for a longer time (68.19±37.72 vs 62.37±40.98 minutes), though duration of hospital stay was shorter (19.41±6.22 vs 22.13±12.3 days). Mechanical ventilation time was likewise shorter (22.41±18.45 vs 23.15±19.88 minutes), but the occurrence of arrhythmia was greater (23 percent vs 4.2 percent).

Multiple regression analysis identified postoperative blood glucose (t, 4.88; p<0.001) and ejection fraction (t, –6.02; p<0.001) as significant predictors of the length of ICU stay. MODD, on the other hand, was significantly associated with arrhythmia incidence (B, 1.513, 95 percent CI, 1.14–2.01; p=0.004).

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Jairia Dela Cruz, 3 days ago
Nonsmall cell lung cancer (NSCLC) patients harbouring sensitive EGFR mutations may fare well with the third-generation tyrosine kinase inhibitor osimertinib as an upfront therapy, with the results of a network meta-analysis showing that the drug tops other currently available options in terms of progression-free survival and tolerability.
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.