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Saras Ramiya, 18 hours ago
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Roshini Claire Anthony, 6 days ago

Overweight or obese patients taking lorcaserin as an appetite suppressant may have the added benefit of a reduced risk of incident diabetes, according to results of the CAMELLIA-TIMI 61* trial presented at EASD 2018.

Glucocorticoids up risk of vertebral fractures in RA patients

07 May 2018

The risk of vertebral fractures increases with longer duration and higher dose of oral glucocorticoids (GCs) in patients with rheumatoid arthritis (RA), but the dose and duration of GC do not contribute to the risk of hip and nonvertebral/nonhip fractures, reports a recent study.

The investigators observed 11,599 fracturs in 9,964 out of 138,240 patients with RA. Of these, 68.2 percent used oral GC for >3 months during follow-up.

Based on adjusted analysis, the risk of vertebral fractures was increased by duration of GC ≥6 months (odds ratio [OR], 1.76; p<0.01), mean dose of GC ≥2.5 mg (OR range, 1.37–1.71; p<0.01) and highest daily dose of GC ≥10 mg (OR range, 1.23–1.75; p<0.03). However, duration and dose of oral GC did not increase the risk of hip and nonvertebral/nonhip fractures in patients with RA.

Results were consistent in RA patients without osteoporosis.

To establish a retrospective cohort of patients with RA ≥19 years old, the investigators used the Korean National Healthcare Claims database from 2010. They followed these patients through December 2013 and calculated the incidence rates of total and major fractures.

Multivariable logistic regression analyses were used to evaluate the effects of GC dose and duration on fractures. The investigators also examined the influence of GC on fractures in RA patients without a history of osteoporosis.

In a 2004 study, researchers observed a dose dependence of fracture risk for hip, vertebral, nonvertebral and any fractures. Longer duration and continuous pattern of GC use showed a fivefold increased risk of hip fracture and nearly sixfold increased risk of vertebral fracture. Hip and vertebral fracture risks further increased by sevenfold and 17-fold, respectively, with the combined effect of higher dose, longer duration and continuous pattern of GC use. [Osteoporos Int 2004;15:323-328]

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Most Read Articles
Saras Ramiya, 18 hours ago
Mundipharma has launched Betadine® Natural Defense personal care product range in Malaysia in collaboration with Watsons.
18 Apr 2018
In patients with rheumatoid arthritis (RA), temporary cessation of methotrexate (MTX) treatment for 2 weeks following influenza vaccination appears to improve the immunogenicity of the vaccine without increasing RA disease activity, according to a study.
Jairia Dela Cruz, 03 May 2018
Acute coronary syndrome (ACS) patients with diabetes mellitus, as well as high-risk nondiabetic patients, appear to obtain significant cardioprotection from the addition of ezetimibe to simvastatin, and this benefit is achieved without compromising safety, according to an exploratory analysis of data from IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial).
Roshini Claire Anthony, 6 days ago

Overweight or obese patients taking lorcaserin as an appetite suppressant may have the added benefit of a reduced risk of incident diabetes, according to results of the CAMELLIA-TIMI 61* trial presented at EASD 2018.