Most Read Articles
Pearl Toh, 18 Feb 2016
Treatment with eluxadoline, a new oral medication, relieved two major symptoms of irritable bowel syndrome with diarrhoea (IBS-D) — abdominal pain and diarrhoea, according to a study based on two phase III randomized controlled trials. [N Engl J Med 2016;374:242-253]
Su Ping Chuah, 01 Aug 2014

The Lancet has launched a special series issue that highlights the global HIV epidemic among sex workers, a key but overlooked population for HIV prevention. The series – launched at the 20th International AIDS conference in Melbourne – consists of seven papers that aim to investigate the complex health issues faced by sex workers worldwide, and calls for the decriminalization of sex work, in the global effort to tackle the HIV/AIDS epidemic. [Available at www.thelancet.com/series/HIV-and-sex-workers. Accessed on 23 July 2014]

Tristan Manalac, 2 days ago
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
Roshini Claire Anthony, 20 Mar 2018

Individuals with type 2 diabetes (T2D) who initiate therapy with sodium glucose cotransporter-2 (SGLT-2) inhibitors have lower risks of all-cause death and cardiovascular (CV) outcomes, specifically myocardial infarction (MI) and stroke, compared with those who initiate other glucose-lowering therapies, according to results from the CVD-REAL* 2 study.

Glucocorticoids up risk of vertebral fractures in RA patients

07 May 2018

The risk of vertebral fractures increases with longer duration and higher dose of oral glucocorticoids (GCs) in patients with rheumatoid arthritis (RA), but the dose and duration of GC do not contribute to the risk of hip and nonvertebral/nonhip fractures, reports a recent study.

The investigators observed 11,599 fracturs in 9,964 out of 138,240 patients with RA. Of these, 68.2 percent used oral GC for >3 months during follow-up.

Based on adjusted analysis, the risk of vertebral fractures was increased by duration of GC ≥6 months (odds ratio [OR], 1.76; p<0.01), mean dose of GC ≥2.5 mg (OR range, 1.37–1.71; p<0.01) and highest daily dose of GC ≥10 mg (OR range, 1.23–1.75; p<0.03). However, duration and dose of oral GC did not increase the risk of hip and nonvertebral/nonhip fractures in patients with RA.

Results were consistent in RA patients without osteoporosis.

To establish a retrospective cohort of patients with RA ≥19 years old, the investigators used the Korean National Healthcare Claims database from 2010. They followed these patients through December 2013 and calculated the incidence rates of total and major fractures.

Multivariable logistic regression analyses were used to evaluate the effects of GC dose and duration on fractures. The investigators also examined the influence of GC on fractures in RA patients without a history of osteoporosis.

In a 2004 study, researchers observed a dose dependence of fracture risk for hip, vertebral, nonvertebral and any fractures. Longer duration and continuous pattern of GC use showed a fivefold increased risk of hip fracture and nearly sixfold increased risk of vertebral fracture. Hip and vertebral fracture risks further increased by sevenfold and 17-fold, respectively, with the combined effect of higher dose, longer duration and continuous pattern of GC use. [Osteoporos Int 2004;15:323-328]

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Most Read Articles
Pearl Toh, 18 Feb 2016
Treatment with eluxadoline, a new oral medication, relieved two major symptoms of irritable bowel syndrome with diarrhoea (IBS-D) — abdominal pain and diarrhoea, according to a study based on two phase III randomized controlled trials. [N Engl J Med 2016;374:242-253]
Su Ping Chuah, 01 Aug 2014

The Lancet has launched a special series issue that highlights the global HIV epidemic among sex workers, a key but overlooked population for HIV prevention. The series – launched at the 20th International AIDS conference in Melbourne – consists of seven papers that aim to investigate the complex health issues faced by sex workers worldwide, and calls for the decriminalization of sex work, in the global effort to tackle the HIV/AIDS epidemic. [Available at www.thelancet.com/series/HIV-and-sex-workers. Accessed on 23 July 2014]

Tristan Manalac, 2 days ago
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
Roshini Claire Anthony, 20 Mar 2018

Individuals with type 2 diabetes (T2D) who initiate therapy with sodium glucose cotransporter-2 (SGLT-2) inhibitors have lower risks of all-cause death and cardiovascular (CV) outcomes, specifically myocardial infarction (MI) and stroke, compared with those who initiate other glucose-lowering therapies, according to results from the CVD-REAL* 2 study.