Most Read Articles
Roshini Claire Anthony, 02 Feb 2018

The use of weight loss medications for at least 1 year did little to improve cardiometabolic risk factors in obese adults, according to a systematic review and meta-analysis.

17 Feb 2019
In patients with type 2 diabetes (T2D), sodium-glucose cotransporter 2 (SGLT2) inhibitor monotherapy, particularly canagliflozin, exerts greater effects on weight compared with metformin and dipeptidyl peptidase 4 (DPP-4) inhibitors or gliptins, according to the results of a meta-analysis.
26 Feb 2019
Oral fluoxetine confers beneficial effects in the management of adult and adolescent amblyopia, suggests a recent study.
19 Feb 2019
Preprandial administration of metformin successfully and safely reduces postprandial plasma triglyceride levels, a new study has shown.

Glecaprevir–pibrentasvir regimen effective against genotype 2 HCV in haemodialysis patients

29 Jul 2019

An 8- or 12-week regimen of glecaprevir plus pibrentasvir (G/P) appears to be safe and effective in the treatment of genotype 2 hepatitis C virus (HCV) infection in patients undergoing haemodialysis, as reported in a recent Japanese cohort study.

Researchers followed a total of 27 patients who initiated G/P regimen. Thirteen nonliver cirrhosis (LC) and direct-acting antivirals (DAAs)-naïve patients received the 8-week regimen, while 14 patients with LC (n=13) or history of DAA failure (n=1) received the 12-week regimen.

All but one patient (96.3 percent) achieved sustained virological response at 12 weeks following treatment completion (SVR12). There were two cases of treatment withdrawal: one was at week 11 due to cerebral infarction (which was resolved by conservative management) and the other was at week 2 due to exacerbation of pruritis. The patient who discontinued G/P at week 2 belonged to the 12-week regimen arm and could not achieve SVR12.

Adverse events occurred in 51.9 percent (14/27) of the population, with the most common being pruritus (29.6 percent; 8/27). None of the patients experienced lethal adverse events.

Glecaprevir is a novel HCV NS5A inhibitor, while pibrentasvir is an HCV protease inhibitor. Notably, these drugs could initially reduce the treatment duration for HCV-infected patients without liver cirrhosis. The efficacy of the G/P regimen has also been demonstrated in a previous trial involving patients with severe renal dysfunction, but the treatment duration was standardized to 12 weeks.  [J Gastroenterol 2018;53:557-565; Hepatology 2018;68:1298-1307; N Engl J Med 2017;377:1448-1555]

Therefore, the present data show that a shorter treatment duration with G/P, similar to that of patients without severe renal dysfunction, is highly effective for haemodialysis patients with genotype 2 HCV infection, the researchers said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Pharmacist - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 02 Feb 2018

The use of weight loss medications for at least 1 year did little to improve cardiometabolic risk factors in obese adults, according to a systematic review and meta-analysis.

17 Feb 2019
In patients with type 2 diabetes (T2D), sodium-glucose cotransporter 2 (SGLT2) inhibitor monotherapy, particularly canagliflozin, exerts greater effects on weight compared with metformin and dipeptidyl peptidase 4 (DPP-4) inhibitors or gliptins, according to the results of a meta-analysis.
26 Feb 2019
Oral fluoxetine confers beneficial effects in the management of adult and adolescent amblyopia, suggests a recent study.
19 Feb 2019
Preprandial administration of metformin successfully and safely reduces postprandial plasma triglyceride levels, a new study has shown.