Glaucoma, AMD patients show similar impairment in QoL
Quality of life (QoL) impairments may not be significantly different between glaucoma and age-related macular degeneration (AMD) patients with similar visual acuity, a study suggests.
The study included 92 matched patients with primary open-angle glaucoma (POAG; n=43; mean age 64.88 years; 60.5 percent female; mean best-corrected visual acuity [BCVA], 0.66) and AMD (n=49; mean age 67.48 years; 57.1 percent female; mean BCVA, 0.60). All patients underwent complete ophthalmic examinations including the 24-2 and 10-2 Swedish Interactive Thresholding Algorithm standard visual field tests, and contrast sensitivity with the CSV-1000 HGT instrument.
QoL was assessed using the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25), and the resulting values were converted to scores between 0 and 100 with higher scores indicating better vision-related QoL.
According to the results, NEI-VFQ-25 scores were not significantly different between the POAG and AMD groups (86.44 vs 84.66, respectively; p=0.244). The highest scores were obtained in the POAG subgroup of ‘vision-related dependency’ and in the AMD subgroup of ‘colour and peripheral vision’, whereas the lowest scores were recorded in both the POAG and AMD subgroup of ‘peripheral vision’.
Glaucoma patients specifically scored poorly in the NEI-VFQ-25 domains of ocular pain, colour vision and peripheral vision subgroups compared with the AMD group, while AMD patients did in domains of near and distance vision activities, vision-related social activity, and dependency.
NEI-VFQ-25 scores correlated with contrast sensitivity results and mean defect values in both POAG and AMD groups.
Glaucoma and AMD are two of the most common causes of irreversible blindness and poor vision-specific functioning in adults aged ≥40 years. While ophthalmic examinations facilitate the surveillance of glaucomatous optic neuropathy and AMD, instruments such as the NEI-VFQ-25 help assess outcomes related to QoL, which is an important measure especially since glaucoma and AMD have been shown to have a negative impact on the patients’ life with regard to performance of daily activities. [Clin Ophthalmol 2009;3:433–445; Am J Ophthalmol 2006;141(1 Suppl):S3–S14]
The findings demonstrate that QoL is similarly impaired in POAG and AMD, such that patients with either condition have difficulty performing multiple daily activities compared with normal individuals.