Giving birth at a young age increases risk of T2D
Giving birth at an earlier age appears to increase the risk of developing type 2 diabetes (T2D) later on in life, reports a recent China study.
Researchers enrolled 297,641 women with at least one live birth, of whom 28,141 (mean age, 58.80±9.74 years) had the first birth before 20 years of age, 171,330 (mean age, 50.18±10.62) had the first child between the ages of 20 and 24 years, 87,238 (mean age, 50.11±9.13 years) first gave birth between 25 and 29 years, and 10,932 (mean age, 51.01±10.56 years) had their first delivery ≥30 years.
The fully adjusted logistic regression model showed that those who gave birth the earliest (<20 years: odds ratio [OR], 1.33, 95 percent CI, 1.22–1.44) and between 20–24 years of age (OR, 1.16, 1.10–1.23) were significantly more likely to be diagnosed with T2D relative to those who first gave birth between 25 and 29 years.
Having the first delivery ≥30 years of age did not significantly affect the likelihood of developing T2D (OR, 1.10, 1.00–1.23).
The relationship between age at first birth and T2D risk appeared to be modified by reproductive factors. For instance, in women who had only one child, T2D risk was not significantly affected by age at first delivery.
In contrast, age at menarche did not seem to be a significant modifying factor. The relationship between age at first childbirth and T2D risk was significant in both premenopausal (first delivery <20 years: OR, 1.58, 0.99–2.54) and postmenopausal (OR, 1.33, 1.22–1.45) women.