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Girls more likely to show complete response to EoE treatment

08 Oct 2019

Girls with eosinophilic oesophagitis (EoE) who show initial response to directed therapy will tend to continue to respond well to treatment, a recent study has shown.

Prospectively enrolling 146 children with EoE (mean age at diagnosis, 7.23±4.88 years; 70.5 percent male) into a database, researchers assessed longitudinal patterns of response to treatment. Among the information collected were patient demographics, allergy test results, symptoms, medication compliance, endoscopic results and histologic findings.  

Multivariate regression analysis showed that girls were significantly more likely to show continuous positive response to treatment, defined as having less than 15 eosinophils/hpf in at least 75 percent of follow-up biopsies (odds ratio [OR], 2.95, 95 percent CI, 1.26–7.14; p=0.014). Initial complete response to therapy was also significantly predictive of a sustained response (OR, 9.97, 4.20–26.81; p<0.001).

Aside from complete responders, researchers also identified two other distinct patterns of treatment response: intermittent responders, who had clear biopsies 25–75 percent of the time, and nonresponders, whose biopsies were clear only <25 percent of the time.

Patients in the distinct response trajectories had different characteristics. Intermittent responders, for instance, were more likely to have allergic rhinitis, while complete responders tended to have lower body mass indices. Initial response to proton pump inhibitors also predicted complete response, though this effect was attenuated upon multivariate adjustments.

“It will be interesting to understand whether our findings are broadly applicable to the EoE population because defining optimal chronic EoE management is a pressing need, especially in children,” said researchers.

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Most Read Articles
Pearl Toh, 10 Oct 2019
Adding a LAMA* to the double combination therapy of ICS** plus LABA*** in a single inhaler improves lung function and reduces exacerbations in patients whose asthma is inadequately controlled with the combination treatment, according to the TRIMARAN and TRIGGER# studies presented at ERS 2019.
22 hours ago
Environmental quality and exposure to pollution may play a small part in the development of metabolic diseases, such as diabetes, a new study has found.
Tristan Manalac, 2 days ago
Sleep deprivation impairs adolescents’ long-term retention of classroom material, according to a recent Singapore study.
4 days ago
Eating alone may help in weight management as findings of a recent study suggest that eating with friends lead to higher food intake.