Most Read Articles
5 days ago
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
5 days ago
Ensituximab, a chimeric monoclonal antibody targeting a variant of MUC5AC, shows modest clinical activity with good safety profile in patients with refractory colorectal cancer, according to data from a phase II study.
Roshini Claire Anthony, 30 Jul 2020

Frailty may indicate an increased risk of death from COVID-19, results of the COPE* study showed.

3 days ago
Treatment with tradipitant in patients with idiopathic or diabetic gastroparesis produces meaningful improvements in nausea and vomiting, according to the results of a phase II trial.

Girls more likely to show complete response to EoE treatment

08 Oct 2019

Girls with eosinophilic oesophagitis (EoE) who show initial response to directed therapy will tend to continue to respond well to treatment, a recent study has shown.

Prospectively enrolling 146 children with EoE (mean age at diagnosis, 7.23±4.88 years; 70.5 percent male) into a database, researchers assessed longitudinal patterns of response to treatment. Among the information collected were patient demographics, allergy test results, symptoms, medication compliance, endoscopic results and histologic findings.  

Multivariate regression analysis showed that girls were significantly more likely to show continuous positive response to treatment, defined as having less than 15 eosinophils/hpf in at least 75 percent of follow-up biopsies (odds ratio [OR], 2.95, 95 percent CI, 1.26–7.14; p=0.014). Initial complete response to therapy was also significantly predictive of a sustained response (OR, 9.97, 4.20–26.81; p<0.001).

Aside from complete responders, researchers also identified two other distinct patterns of treatment response: intermittent responders, who had clear biopsies 25–75 percent of the time, and nonresponders, whose biopsies were clear only <25 percent of the time.

Patients in the distinct response trajectories had different characteristics. Intermittent responders, for instance, were more likely to have allergic rhinitis, while complete responders tended to have lower body mass indices. Initial response to proton pump inhibitors also predicted complete response, though this effect was attenuated upon multivariate adjustments.

“It will be interesting to understand whether our findings are broadly applicable to the EoE population because defining optimal chronic EoE management is a pressing need, especially in children,” said researchers.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
5 days ago
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
5 days ago
Ensituximab, a chimeric monoclonal antibody targeting a variant of MUC5AC, shows modest clinical activity with good safety profile in patients with refractory colorectal cancer, according to data from a phase II study.
Roshini Claire Anthony, 30 Jul 2020

Frailty may indicate an increased risk of death from COVID-19, results of the COPE* study showed.

3 days ago
Treatment with tradipitant in patients with idiopathic or diabetic gastroparesis produces meaningful improvements in nausea and vomiting, according to the results of a phase II trial.