Most Read Articles
Roshini Claire Anthony, 11 Dec 2020

Treatment with the nonsteroidal, selective mineralocorticoid receptor antagonist finerenone reduced chronic kidney disease (CKD) progression and cardiovascular (CV) event risk in patients with CKD and type 2 diabetes (T2D), according to the FIDELIO-DKD* study presented at ASN Kidney Week 2020.

Stephen Padilla, 22 Jun 2020
A dietary pattern (DP) characterized by high intakes of eggs, fish, milk, and other dairy products appears to confer protective benefits against incident cardiovascular disease (CVD) in women, reveals a study.

GI bleeding a potential complication of direct anticoagulant use in atrial fibrillation

27 Nov 2020
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Atrial fibrillation (AF) patients receiving direct oral anticoagulants (DOACs) may be at risk of gastrointestinal (GI) bleeding, a recent study has found. This must be taken into consideration when prescribing anticoagulants, particularly to elderly patients.

Researchers conducted a retrospective cohort study including 1,086 AF patients (median age, 73 years; 67.6 percent male), with a special focus on the very elderly (n=112). Most of the participants were prescribed DOAC doses in agreement with existing guidelines, while around a third were underdosed.

Over a total observation period of 2,467.3 patient-years, 112 bleeding events at any site were reported. The resulting incidence rate was 4.5 per 100 person-years. GI bleeding accounted for more than half of the cases (n=66), with an incidence rate of 2.7 per 100 person-years.

Intracranial bleeding was reported in nine patients (0.4 per 100 person-years), while the remaining 37 cases occurred across various sites. Major adverse cardiac and cardiovascular events (MACCEs) occurred in 110 patients, yielding an incidence rate of 4.7 per 100 person-years.

Cox proportional hazards analysis found that being ≥85 years of age was a significant risk factor for all bleeding events (adjusted hazard ratio [HR], 2.15, 95 percent confidence interval [CI], 1.29–3.58; p=0.003), particularly GI bleeding (adjusted HR, 2.256; 95 percent CI, 1.165–4.366; p=0.016).

Other important risk factors for bleeding included chronic kidney disease and being medicated with low-dose aspirin or nonsteroidal anti-inflammatory drugs.

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Most Read Articles
Roshini Claire Anthony, 11 Dec 2020

Treatment with the nonsteroidal, selective mineralocorticoid receptor antagonist finerenone reduced chronic kidney disease (CKD) progression and cardiovascular (CV) event risk in patients with CKD and type 2 diabetes (T2D), according to the FIDELIO-DKD* study presented at ASN Kidney Week 2020.

Stephen Padilla, 22 Jun 2020
A dietary pattern (DP) characterized by high intakes of eggs, fish, milk, and other dairy products appears to confer protective benefits against incident cardiovascular disease (CVD) in women, reveals a study.