Most Read Articles
Tristan Manalac, 4 days ago
The causes, presentations and management of anaphylaxis vary considerably with age, according to a recent Singapore study, which reported that children are more likely to present with food anaphylaxis, while drug anaphylaxis is more common in adults.
Pearl Toh, 3 days ago
Low-density lipoprotein cholesterol (LDL-C) levels remained high in many patients with stable or acute coronary heart disease (CHD) in Asia, despite having a very high risk of recurrent cardiovascular (CV) events, indicating that the use of lipid-lowering therapies and lipid monitoring were inadequate.
13 Sep 2018
Substituting diets high in carbohydrates with those high in monounsaturated fatty acids in the context of low saturated fatty acids do not appear to yield favourable effects on blood pressure, according to a meta-analysis.
2 days ago
There is a strong association between smoking duration and colorectal polyps, independent of smoking intensity, cessation and other potential confounders, reports a recent study. Such association is more robust with distal rather than proximal polyps, and with serrated polyps rather than adenomas.

GH therapy improves height in childhood cancer survivors

09 Sep 2018

Treatment with growth hormone therapy (GHT) among childhood cancer survivors (CCSs) increases height and may improve lipid profiles and quality of life, according to the results of a systematic review and meta-analysis. In addition, GHT does not appear to increase the risk of diabetes or the development of secondary tumours.

“[C]lose monitoring for such complications remains warranted due to uncertainty in the current evidence,” the authors cautioned.

Multiple databases were searched for randomized and observational studies. Pairs of independent reviewers selected studies and collected data. Outcomes across studies were pooled using random effects meta-analysis.

Twenty-nine observational studies at moderate-to-high risk of bias were included, of which 16 compared CCSs on GHT with those not on GHT (512 patients; GH dose, 0.3–0.9 IU/kg/week). A significant association existed between GHT and height gain (standard deviation score, 0.61; 95 percent CI, 0.08–1.13). Moreover, GHT did not significantly correlate with the occurrence of secondary tumours (odds ratio [OR], 1.10; 0.72–1.67) or tumour recurrence (OR, 0.57; 0.31–1.02).

Thirteen studies compared CCSs on GHT with normal age- or sex-matched controls or controls with idiopathic GHD or short stature. GHT was shown to be associated with either improved or unchanged risk of diabetes, lipid profiles and metabolic syndrome. GHT also correlated with improvements in quality of life.

“GH deficiency is common among CCSs with history of tumours, surgery and/or radiotherapy involving the hypothalamus-pituitary region,” the authors noted.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Tristan Manalac, 4 days ago
The causes, presentations and management of anaphylaxis vary considerably with age, according to a recent Singapore study, which reported that children are more likely to present with food anaphylaxis, while drug anaphylaxis is more common in adults.
Pearl Toh, 3 days ago
Low-density lipoprotein cholesterol (LDL-C) levels remained high in many patients with stable or acute coronary heart disease (CHD) in Asia, despite having a very high risk of recurrent cardiovascular (CV) events, indicating that the use of lipid-lowering therapies and lipid monitoring were inadequate.
13 Sep 2018
Substituting diets high in carbohydrates with those high in monounsaturated fatty acids in the context of low saturated fatty acids do not appear to yield favourable effects on blood pressure, according to a meta-analysis.
2 days ago
There is a strong association between smoking duration and colorectal polyps, independent of smoking intensity, cessation and other potential confounders, reports a recent study. Such association is more robust with distal rather than proximal polyps, and with serrated polyps rather than adenomas.