Most Read Articles
Roshini Claire Anthony, 10 Jan 2020

The rates of ovarian cancer in Singapore have more than doubled over the past 40 years, with evidence of variation between the main ethnic groups, a recent study has shown.

Pearl Toh, 19 Feb 2020
Pregnant women with inadequate knowledge on health are more likely to have undesirable maternal outcomes during delivery and adverse outcomes in their offspring than those who were well informed, according to a large cohort study presented at SMFM 2020 Annual Pregnancy Meeting.
01 Sep 2018

Gangliosides and docosahexaenoic acid (DHA) play critical roles in early childhood brain development. 

29 Jan 2020
The risk of adverse pregnancy outcomes appears to be low in women treated with vedolizumab for inflammatory bowel disease, a study has found.

Gestational diabetes confers long-term type 2 diabetes risk

06 Feb 2020

The long-term risk of type 2 diabetes or impaired glucose tolerance is common in women with gestational diabetes, reports a new China study.

Researchers conducted a prospective nested case-cohort study including 121 women (mean age, 50.3 years) who were followed for a mean of 22.5 years. Oral glucose tolerance tests were conducted at 8, 15 and 22 years.

Twenty participants (16.9 percent) were identified to have type 2 diabetes over the follow-up period, with half being newly diagnosed. Forty-four had either diabetes or abnormal glucose tolerance, and 24 (20.3 percent) had metabolic syndrome.

Multiple logistic regression analysis revealed that a history of gestational diabetes mellitus or gestational impaired glucose tolerance (GDM/GIGT) significantly increased the risk of type 2 diabetes or abnormal glucose tolerance at follow-up, even after adjusting for potential confounders (odds ratio [OR], 2.78, 95 percent confidence interval [CI], 1.18–6.55; p=0.02).

Longitudinal assessment was possible in 943 women. At the 8-year follow-up, 40.3 percent of the GDM/GIGT participants were dysglycaemic, as opposed to only 17.7 percent of those with normal glucose tolerance (p=0.001). This gap remained significant even after 22 years of follow-up (52.6 percent vs 30.0 percent; p=0.025). Two-hour glucose levels were similarly longitudinally elevated in GDM/GIGT participants.

“There is a need to raise awareness concerning this at-risk population and to implement active surveillance to prevent associated morbidity and mortality,” said researchers.

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Most Read Articles
Roshini Claire Anthony, 10 Jan 2020

The rates of ovarian cancer in Singapore have more than doubled over the past 40 years, with evidence of variation between the main ethnic groups, a recent study has shown.

Pearl Toh, 19 Feb 2020
Pregnant women with inadequate knowledge on health are more likely to have undesirable maternal outcomes during delivery and adverse outcomes in their offspring than those who were well informed, according to a large cohort study presented at SMFM 2020 Annual Pregnancy Meeting.
01 Sep 2018

Gangliosides and docosahexaenoic acid (DHA) play critical roles in early childhood brain development. 

29 Jan 2020
The risk of adverse pregnancy outcomes appears to be low in women treated with vedolizumab for inflammatory bowel disease, a study has found.