Most Read Articles
Stephen Padilla, 06 Aug 2020
The novel coronavirus disease (COVID-19) pandemic appears to have a significant impact on oncological care, according to a study, which stresses the need for psycho-oncological support for cancer patients.
01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
06 Aug 2020
Sodium–glucose cotransporter-2 (SGLT-2) inhibitors increase the risk for diabetic ketoacidosis (DKA) by almost threefold, with molecule-specific analyses suggesting a class effect, according to a study.
Stephen Padilla, 3 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.

GERD questionnaires predict erosive disease in obese people

04 Oct 2019

Gastroesophageal reflux disease questionnaires (GERDQ) may help predict erosive oesophagitis (EE) among obese individuals with GERD, a recent study has found.

Using the (GERDQ) and Nocturnal GERD Symptom Severity Impact Questionnaire (N-GSSIQ), researchers assessed 242 consecutive patients (mean age, 37.8±11.8 years; 46.3 percent male) before undergoing routine oesophagogastroduodenoscopy. Outcomes included the presence and grade of EE, presence and size of hiatal hernia, and the gastroesophageal flap valve endoscopic grading.

Majority of the participants (62.4 percent) had GERD, defined as GERDQ score 8, presence of EE or daily use of proton pump inhibitors. In an additional 12.8 percent, clinically important GERD was present but silent.

Questionnaire findings appeared to be reasonably discriminative between those with vs without EE. For instance, erosive disease was significantly more common in those with GERDQ scores 8 vs <8 (70.6 percent vs 27.2 percent; p<0.001) and in those with vs without hiatal hernia (69.7 percent vs 36.9 percent; p<0.001).

Similarly, EE was present in higher frequencies in participants with severe nocturnal gastroesophageal reflux symptoms (65.6 percent vs 37.9 percent; p=0.004).

Multivariate logistic regression analysis found that GERDQ scores 8 (odds ratio [OR], 6.3, 95 percent CI, 3.0–13.1), the presence of hiatal hernia (OR, 4.2, 1.6–10.7), an abnormal Hill grade (OR, 2.7, 1.4–5.4) and the use of tobacco (OR, 2.5, 1.2–4.9) were significant and independent risk factors for EE in the study population.

However, the composite risk factor including GERDQ 8 and severe nocturnal symptoms had poor overall accuracy for predicting EE, with 90 percent specificity and 20.7 percent sensitivity.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Gastroenterology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Stephen Padilla, 06 Aug 2020
The novel coronavirus disease (COVID-19) pandemic appears to have a significant impact on oncological care, according to a study, which stresses the need for psycho-oncological support for cancer patients.
01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
06 Aug 2020
Sodium–glucose cotransporter-2 (SGLT-2) inhibitors increase the risk for diabetic ketoacidosis (DKA) by almost threefold, with molecule-specific analyses suggesting a class effect, according to a study.
Stephen Padilla, 3 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.