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GERD frequency, severity predict Barrett’s oesophagus

12 Nov 2018

Individuals with severe and frequent gastro-oesophageal reflux disease (GERD) are at increased risk of Barrett’s oesophagus (BE), especially in the absence of frequent proton pump inhibitor (PPI) use, a recent study has found. Family history of BE and early age of symptom onset are strong predictors of BE among people with GERD.

A total of 953 patients were interviewed (320 with BE, 316 with GERD who lacked BE and 317 population controls). Risk of BE was highest among patients with the most frequent and severe GERD symptoms (odds ratio [OR], 27.00; 95 percent CI, 14.52–50.21), nocturnal symptoms (OR, 5.40; 3.81–7.72) and family history of GERD (OR, 2.55; 1.80–3.62) or BE (OR, 10.08; 2.83–35.84) compared with controls.

At least weekly PPI use was a risk factor for BE (OR, 9.85; 6.54–14.84), but GERD symptoms were not strongly associated with the risk of BE among PPI users in the general population. Onset of GERD symptoms before 30 years of age (OR, 1.93; 1.15–3.22) and a family history of BE (OR, 3.64; 1.50–8.83) predicted BE among those with GERD vs controls.

“These findings may improve identification of patients at highest risk for BE,” the investigators said.

A case-control study was conducted within the Kaiser Permanente Northern California population. Cases were newly diagnosed with BE. The investigators contrasted cases with population controls to identify risk factors in the general population, and with GERD patients who lacked BE to identify risk factors only among patients with GERD.

“GERD is a known risk factor for oesophageal adenocarcinoma, but the ability of GERD symptom frequency and severity to predict presence of its putative precursor lesion, BE, is less well-defined in large, community-based populations,” the investigators said.

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Most Read Articles
6 days ago
The consumption of red and processed meats does not seem to affect the likelihood of symptom relapse among Crohn’s disease (CD) patients in relapse, reports a recent study.
Pearl Toh, 4 days ago
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from a large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
6 days ago
Treatment with metformin may improve whole-body and peripheral insulin resistance (IR) in youth who are overweight/obese with type 1 diabetes (T1D), according to a study.
4 days ago
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.