Most Read Articles
Audrey Abella, 16 Oct 2019
The PD-1* inhibitor nivolumab showed significant survival benefit and a favourable safety profile than taxane chemotherapy in patients with unresectable advanced or recurrent oesophageal squamous cell carcinoma (OSCC) refractory or intolerant to previous fluoropyrimidine- and platinum-based chemotherapy, according to the findings of ATTRACTION-3** presented at ESMO 2019.
03 Oct 2019
Early enteral nutrition (EEN) speeds up the recovery of gastrointestinal function after laparoscopic common bile duct exploration (LCBDE), according to a study. However, EEN also increases complications such as diarrhoea and abdominal distension.
01 Sep 2019
A third of Clostridium difficile infection (CDI) patients with cirrhosis have been readmitted in a span of 30 days primarily due to recurrent CDI, a recent study has found. In addition, there is a high rate of mortality linked to CDI in patients with cirrhosis, in which a poor prognosis is predicted by decompensation and 30-day readmission.
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Use of proton pump inhibitors contributes to increased risk of cholangitis, a large cohort study suggests.

GERD common among obese patients undergoing bariatric surgery

07 Jun 2019

Gastro-oesophageal reflux disease (GERD) is common among obese patients qualified for bariatric surgery, underscoring the need for preoperative endoscopic assessment, a recent study has shown.

Researchers enrolled 242 consecutive obese patients (mean age, 37.8±11.8 years; 53.7 percent female) undergoing routine oesophagogastroduodenoscopy. Prior to the operation, participants were made to complete the Nocturnal Symptom Severity Impact (N-GSSIQ) and the GERD questionnaire (GERDQ).

GERD, defined as GERDQ score 8, the presence of erosive oesophagitis (EE) or daily use of proton pump inhibitors, was identified in 62.4 percent of the participants. Thirty-one more patients (12.8 percent) had silent or inconspicuous, yet important, GERD.

Excluding 49 participants without erosive disease, researchers found that EE was significantly more common in patients with GERDQ score 8 (70.6 percent vs 27.2 percent; p<0.001), with hiatal hernia (69.7 percent vs 36.9 percent; p<0.001) and with severe nocturnal GER symptoms (65.6 percent vs 37.9 percent; p=0.004).

Multivariate logistic regression analysis confirmed that GERDQ 8 (odds ratio [OR], 6.3, 95 percent CI, 3.0–13.1) and the presence of hiatal hernia (OR, 4.2, 1.6–10.7) were significantly predictive of EE. The same was true for having an abnormal Hill grade (OR, 2.7, 1.4–5.4) and tobacco use (OR, 2.5, 1.2–4.9).

However, a pre-endoscopic assessment combining GERDQ and the presence of nocturnal reflux symptoms yielded high specificity (90 percent), but a sensitivity value of only 20.7 percent. The negative and positive predictive values were 68.9 percent and 51.5 percent, respectively. This highlights the need for preoperative endoscopic assessment, said researchers.

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Most Read Articles
Audrey Abella, 16 Oct 2019
The PD-1* inhibitor nivolumab showed significant survival benefit and a favourable safety profile than taxane chemotherapy in patients with unresectable advanced or recurrent oesophageal squamous cell carcinoma (OSCC) refractory or intolerant to previous fluoropyrimidine- and platinum-based chemotherapy, according to the findings of ATTRACTION-3** presented at ESMO 2019.
03 Oct 2019
Early enteral nutrition (EEN) speeds up the recovery of gastrointestinal function after laparoscopic common bile duct exploration (LCBDE), according to a study. However, EEN also increases complications such as diarrhoea and abdominal distension.
01 Sep 2019
A third of Clostridium difficile infection (CDI) patients with cirrhosis have been readmitted in a span of 30 days primarily due to recurrent CDI, a recent study has found. In addition, there is a high rate of mortality linked to CDI in patients with cirrhosis, in which a poor prognosis is predicted by decompensation and 30-day readmission.
26 Sep 2019
Use of proton pump inhibitors contributes to increased risk of cholangitis, a large cohort study suggests.