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Tristan Manalac, 18 Nov 2020
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Genetic variants linked to vasomotor symptoms

11 Nov 2020

Associations exist between genetic variants and vasomotor symptoms (VMS), such as hot flashes and night sweats, and these relations are not limited to variations in sex-steroid metabolism genes, according to a recent study.

The investigators searched PubMed and Embase databases in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidance. Studies assessing the associations between genetic variation and VMS were included. Those focusing on medication interventions or prevention or treatment of breast cancer were excluded.

A total of 202 unique citations were identified, of which 18 met the eligibility criteria. Sample sizes ranged from 51 to 17,695. Eleven studies had fewer than 500 participants, while two had 1,000.

Genetic variants in 14 of the 26 genes assessed in candidate gene studies showed statistically significant associations with VMS. Seven studies focused on the cytochrome P450 family 1 subfamily A member 1 (CYP1B1) gene. However, the strength and statistical significance of associations of CYP1B1 variants with VMS were inconsistent.

In a genome-wide association study, 14 single-nucleotide variants in the tachykinin receptor 3 gene showed statistically significant associations with VMS.

Of note, the heterogeneity across trials with regard to VMS measurement methods and effect measures precluded quantitative meta-analysis. Moreover, there were few studies of each specific genetic variant. Further research is warranted to confirm and extend these findings, according to the investigators.

Nearly seven in 10 women report experiencing VMS, but the aetiology of VMS is not clearly understood, they noted.

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Most Read Articles
4 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
3 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 18 Nov 2020
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).