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13 Feb 2020
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Female cancer survivors who undergo fertility preservation before cancer treatment often use their stored gametes/embryos. This highlights the effectiveness of pre-cancer fertility preservation, according to a study presented at ESHRE 2020.

 

Genetic testing vital for lung cancer diagnosis, management

Dr Joslyn Ngu
04 Dec 2017

Genetic testing has changed the landscape of lung cancer and every patient needs to undergo testing, says a specialist.

Testing allows for the determination of actionable genetic alterations in lung cancer and is vital as it allows better treatment, said clinical oncologist Dr Tho Lye Mun. Research has found that patients with an oncogenic driver mutation who were given targeted therapy had better survival rate than those who did not receive targeted therapy and patients without an oncogenic driver. [JAMA 2014;311(19):1998–2006]

With the advancement in genetic testing, diagnosing lung cancer now involves an additional step. Besides conventional diagnosis using morphological or basic immunohistochemical features, for example to differentiate small cell lung cancer versus non-small cell lung carcinoma (NSCLC), identifying actionable genetic alterations such as EGFR, ALK , ROS-1 and PDL-1 should also be part of routine lung cancer diagnosis, said Tho.

The ability to classify patients in a more precise manner allows for more appropriate therapeutic strategy and for patients to receive the maximum effect of molecularly targeted drugs or immunotherapy. 

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Most Read Articles
13 Feb 2020
At the recent National Haematology Expert Meeting 2019, a panel of experts was convened to discuss the role of targeted therapy in the management of haematological malignancies. Highlights of their lectures are summarised below.
12 Jun 2020
Drawing from experience as a key investigator in landmark clinical trials (including PALOMA, MONALEESA and MONARCH), and his clinical experience with CDK4/6 inhibitors, Dr Rafael Villanueva Vázquez shares his insights into the current evidence of using CDK4/6 inhibitors to treat HR+/HER2- ABC.
Roshini Claire Anthony, 5 days ago

Female cancer survivors who undergo fertility preservation before cancer treatment often use their stored gametes/embryos. This highlights the effectiveness of pre-cancer fertility preservation, according to a study presented at ESHRE 2020.