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Genetic susceptibility influences weight-loss mediated BP reduction

12 Jan 2020

Genetic predisposition to elevated blood pressure (BP) may affect BP changes in response to weight-loss diets, such that individuals with higher genetic susceptibility exhibit less decrease in BP levels, a study has found. Moreover, this effect differs by protein intake.

Researchers evaluated the changes in systolic and diastolic BP (SBP/DBP) among 692 overweight or obese adults (mean age, 51.4 years; 61.1 percent female; mean body mass index [BMI], 32.7 kg/m2; 84.2 percent Whites) who were randomly assigned to one of four diets varying in macronutrient content for 2 years.

Participants were grouped according to polygenic scores (PGS) for SBP and DBP calculated based on BP-associated single nucleotide polymorphisms.

During the 2-year intervention, the reductions observed in SBP levels were significantly greater for participants in the bottom vs upper tertile of PGS (6 months: −3.84 vs −1.61; 12 months: −4.76 vs −2.75; 24 months: 2.49 vs 1.63; p=0.001). The same was observed for changes in DBP levels (6 months: −3.09 vs −1.34; 12 months: −2.69 vs −1.44; 24 months: 1.82 vs 0.53; p<0.001).

There was a notable gene–diet interaction on changes in SBP from baseline to 24 months (p-interaction=0.009). In the group of participants assigned to a high-protein diet, those with lower SBP-PGS achieved greater decreases in SBP at months 6 (p=0.018), 12 (p=0.007) and 24 (p=0.089). No such effect was seen in the group of participants assigned to an average-protein diet.

The present data support a personalized diet approach in preventing hypertension, according to the researchers. Overweight and obese individuals with a lower SBP-PGS should see greater weight-loss mediated BP reduction and may benefit even more from consuming a high-protein weight-loss diet.

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Most Read Articles
Pearl Toh, 12 Sep 2020
Early initiation of rhythm-control therapy led to a significantly reduced risk of major adverse cardiovascular (CV) outcomes compared with usual care (typically rate control) in patients with newly diagnosed atrial fibrillation (AF) at risk of stroke, reveals the EAST-AFNET 4* trial presented at ESC 2020.
Audrey Abella, 16 Sep 2020
The final results of EVAPORATE* reinforce the plaque-regressing potential of icosapent ethyl (IPE) in patients on statins for elevated triglycerides.