Most Read Articles
Stephen Padilla, 27 Jun 2019
Accelerated cognitive decline is significantly associated with incident coronary heart disease (CHD) after, but not before or immediately following, ischaemic events, suggests a recent study.
12 Jan 2020
Levels of high-sensitivity C-reactive protein (hs-CRP) in the serum are predictive of more severe coronary artery disease (CAD), reports a recent study.
6 days ago
Bicuspid and tricuspid aortic valve patients have comparable 30-day and 1-year mortality outcomes after transcatheter aortic valve replacement (TAVR), reports a recent meta-analysis. Rates of stroke and new pacemaker implants are likewise similar.
Christina Lau, 02 Jan 2020

A left ventricular ejection fraction (LVEF) cut-off of 60 percent may identify patients with heart failure (HF) with mid-range or preserved ejection fraction (mrEF or pEF) who could benefit from drug therapy.

Genetic susceptibility influences weight-loss mediated BP reduction

12 Jan 2020

Genetic predisposition to elevated blood pressure (BP) may affect BP changes in response to weight-loss diets, such that individuals with higher genetic susceptibility exhibit less decrease in BP levels, a study has found. Moreover, this effect differs by protein intake.

Researchers evaluated the changes in systolic and diastolic BP (SBP/DBP) among 692 overweight or obese adults (mean age, 51.4 years; 61.1 percent female; mean body mass index [BMI], 32.7 kg/m2; 84.2 percent Whites) who were randomly assigned to one of four diets varying in macronutrient content for 2 years.

Participants were grouped according to polygenic scores (PGS) for SBP and DBP calculated based on BP-associated single nucleotide polymorphisms.

During the 2-year intervention, the reductions observed in SBP levels were significantly greater for participants in the bottom vs upper tertile of PGS (6 months: −3.84 vs −1.61; 12 months: −4.76 vs −2.75; 24 months: 2.49 vs 1.63; p=0.001). The same was observed for changes in DBP levels (6 months: −3.09 vs −1.34; 12 months: −2.69 vs −1.44; 24 months: 1.82 vs 0.53; p<0.001).

There was a notable gene–diet interaction on changes in SBP from baseline to 24 months (p-interaction=0.009). In the group of participants assigned to a high-protein diet, those with lower SBP-PGS achieved greater decreases in SBP at months 6 (p=0.018), 12 (p=0.007) and 24 (p=0.089). No such effect was seen in the group of participants assigned to an average-protein diet.

The present data support a personalized diet approach in preventing hypertension, according to the researchers. Overweight and obese individuals with a lower SBP-PGS should see greater weight-loss mediated BP reduction and may benefit even more from consuming a high-protein weight-loss diet.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Cardiology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Stephen Padilla, 27 Jun 2019
Accelerated cognitive decline is significantly associated with incident coronary heart disease (CHD) after, but not before or immediately following, ischaemic events, suggests a recent study.
12 Jan 2020
Levels of high-sensitivity C-reactive protein (hs-CRP) in the serum are predictive of more severe coronary artery disease (CAD), reports a recent study.
6 days ago
Bicuspid and tricuspid aortic valve patients have comparable 30-day and 1-year mortality outcomes after transcatheter aortic valve replacement (TAVR), reports a recent meta-analysis. Rates of stroke and new pacemaker implants are likewise similar.
Christina Lau, 02 Jan 2020

A left ventricular ejection fraction (LVEF) cut-off of 60 percent may identify patients with heart failure (HF) with mid-range or preserved ejection fraction (mrEF or pEF) who could benefit from drug therapy.