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29 Jan 2020
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Pearl Toh, 10 Feb 2020
Contrary to popular concern, use of statins was not associated with a greater decline in memory or cognition in the elderly over 6 years, according to data from the observational MAS*.
Stephen Padilla, 23 May 2019
A recent study has shown an association between regular use of glucosamine supplement to relieve osteoarthritis pain and lower risk of cardiovascular disease (CVD) events.
Jairia Dela Cruz, 2 days ago
A wearable arrhythmia detection device, the AliveCor KardiaBand (KB), demonstrates moderate accuracy for diagnosing atrial fibrillation (AF) in comparison with a 12-lead electrocardiogram (ECG), as shown in a recent study. However, combining the automated device diagnosis with the electrophysiologists (EP) interpretation of unclassified readings improves overall accuracy.

Genetic susceptibility influences weight-loss mediated BP reduction

12 Jan 2020

Genetic predisposition to elevated blood pressure (BP) may affect BP changes in response to weight-loss diets, such that individuals with higher genetic susceptibility exhibit less decrease in BP levels, a study has found. Moreover, this effect differs by protein intake.

Researchers evaluated the changes in systolic and diastolic BP (SBP/DBP) among 692 overweight or obese adults (mean age, 51.4 years; 61.1 percent female; mean body mass index [BMI], 32.7 kg/m2; 84.2 percent Whites) who were randomly assigned to one of four diets varying in macronutrient content for 2 years.

Participants were grouped according to polygenic scores (PGS) for SBP and DBP calculated based on BP-associated single nucleotide polymorphisms.

During the 2-year intervention, the reductions observed in SBP levels were significantly greater for participants in the bottom vs upper tertile of PGS (6 months: −3.84 vs −1.61; 12 months: −4.76 vs −2.75; 24 months: 2.49 vs 1.63; p=0.001). The same was observed for changes in DBP levels (6 months: −3.09 vs −1.34; 12 months: −2.69 vs −1.44; 24 months: 1.82 vs 0.53; p<0.001).

There was a notable gene–diet interaction on changes in SBP from baseline to 24 months (p-interaction=0.009). In the group of participants assigned to a high-protein diet, those with lower SBP-PGS achieved greater decreases in SBP at months 6 (p=0.018), 12 (p=0.007) and 24 (p=0.089). No such effect was seen in the group of participants assigned to an average-protein diet.

The present data support a personalized diet approach in preventing hypertension, according to the researchers. Overweight and obese individuals with a lower SBP-PGS should see greater weight-loss mediated BP reduction and may benefit even more from consuming a high-protein weight-loss diet.

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Most Read Articles
29 Jan 2020
Several high-density lipoprotein (HDL) functionality parameters, which are linked to HDL roles on cholesterol metabolism, endothelial protection and antioxidant/anti-inflammatory defence, contribute to an increased risk of incident acute coronary syndromes and its manifestations in individuals at high risk of cardiovascular disease, a study reports.
Pearl Toh, 10 Feb 2020
Contrary to popular concern, use of statins was not associated with a greater decline in memory or cognition in the elderly over 6 years, according to data from the observational MAS*.
Stephen Padilla, 23 May 2019
A recent study has shown an association between regular use of glucosamine supplement to relieve osteoarthritis pain and lower risk of cardiovascular disease (CVD) events.
Jairia Dela Cruz, 2 days ago
A wearable arrhythmia detection device, the AliveCor KardiaBand (KB), demonstrates moderate accuracy for diagnosing atrial fibrillation (AF) in comparison with a 12-lead electrocardiogram (ECG), as shown in a recent study. However, combining the automated device diagnosis with the electrophysiologists (EP) interpretation of unclassified readings improves overall accuracy.